The Role of Immune Cells in DKD: Mechanisms and Targeted Therapies.

Autor:	Peng QY; Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan, People's Republic of China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, People's Republic of China., An Y; Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan, People's Republic of China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, People's Republic of China., Jiang ZZ; Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan, People's Republic of China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, People's Republic of China., Xu Y; Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.; Metabolic Vascular Disease Key Laboratory of Sichuan Province, Sichuan, People's Republic of China.; Sichuan Clinical Research Center for Nephropathy, Luzhou, Sichuan, People's Republic of China.
Jazyk:	angličtina
Zdroj:	Journal of inflammation research [J Inflamm Res] 2024 Apr 06; Vol. 17, pp. 2103-2118. Date of Electronic Publication: 2024 Apr 06 (Print Publication: 2024).
DOI:	10.2147/JIR.S457526
Abstrakt:	Diabetic kidney disease (DKD), is a common microvascular complication and a major cause of death in patients with diabetes. Disorders of immune cells and immune cytokines can accelerate DKD development of in a number of ways. As the kidney is composed of complex and highly differentiated cells, the interactions among different cell types and immune cells play important regulatory roles in disease development. Here, we summarize the latest research into the molecular mechanisms underlying the interactions among various immune and renal cells in DKD. In addition, we discuss the most recent studies related to single cell technology and bioinformatics analysis in the field of DKD. The aims of our review were to explore immune cells as potential therapeutic targets in DKD and provide some guidance for future clinical treatments. Competing Interests: The authors declare that they have no competing interests in this work. (© 2024 Peng et al.)
Databáze:	MEDLINE
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