Significance of Estrogen/Progesterone Receptor Expression in Metaplastic Breast Carcinoma.

Autor: Hashmi AA; FRCPath, Department of Histopathology, Liaquat National Hospital and Medical College, Karachi 74800, Pakistan., Mallick BA; Zainab Panjwani Memorial Hospital, Karachi 74800, Pakistan.; Emergency Medicine, Al-Rayaz Hospital, Karachi 75850, Pakistan.; Prime Cardiology of Nevada, Las Vegas 89128, USA., Rashid K; Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi 74200, Pakistan., Malik UA; Department of Internal Medicine, Aga Khan University, Karachi 74800, Pakistan., Zia S; Department of Pathology, Jinnah Sindh Medical University, Karachi 75510, Pakistan., Zia F; Department of Pathology, Jinnah Sindh Medical University, Karachi 75510, Pakistan., Irfan M; Department of Biostatistics, Liaquat National Hospital and Medical College, Karachi 74800, Pakistan.
Jazyk: angličtina
Zdroj: Disease markers [Dis Markers] 2024 Apr 03; Vol. 2024, pp. 2540356. Date of Electronic Publication: 2024 Apr 03 (Print Publication: 2024).
DOI: 10.1155/2024/2540356
Abstrakt: Introduction: Metaplastic breast carcinoma (MBC) is a rare subgroup of breast neoplasms associated with adverse outcomes because of its aggressive nature. Typically, MBCs show triple-negative hormone receptor (HR) status. Determining the HR status of breast cancer is an integral part because it is an important prognostic factor and helps in the treatment course of the disease. This study aimed to determine the HR status of MBC, its significance, and its association with various clinicopathological parameters.
Methods: This was a retrospective study conducted at the Department of Histopathology, Liaquat National Hospital. A total of 140 biopsy-proven cases of MBC were enrolled in the study. Clinical and pathological data were retrieved from the institutes' archives. Immunohistochemical studies were conducted to determine the estrogen receptor (ER) and progesterone receptor (PR) status.
Results: The mean age of MBC in our population was found to be 52.18 ± 12.19 years. The HR positivity rate in our population was found to be 32.9%. A significant association was found between HR status and tumor laterality, tumor size, tumor grade, tumor stage, and recurrence. ER/PR-negative MBCs were most probably associated with higher grade and higher tumor stage and were larger in size (6.62 ± 3.43 cm) than ER/PR-positive MBCs (4.20 ± 1.88 cm). Moreover, ER/PR-positive MBCs showed a higher recurrence rate than ER/PR-negative MBCs (43.5% vs. 25.5%, respectively). No statistically significant relationship was found between HR status and patient age, histological subtype, or survival rate.
Conclusion: MBC is a rare breast neoplasm. MBC was found to be triple negative in most cases, but a significant percentage were HR (ER/PR) positive. Moreover, we found an association between HR status and various clinicopathological features, indicating that HR status is a significant predictor of MBC prognosis.
Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(Copyright © 2024 Atif Ali Hashmi et al.)
Databáze: MEDLINE
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