Sulfated Polysaccharides with Anticoagulant Potential: A Review Focusing on Structure-Activity Relationship and Action Mechanism.

Autor: Chen Q; School of Biology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu, 215500, China.; College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, Zhejiang, 315000, China., Zhang M; School of Biology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu, 215500, China.; College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, Jiangsu, 225000, China., Liu Y; College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, Zhejiang, 315000, China., Liu W; School of Biology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu, 215500, China., Peng C; School of Biology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu, 215500, China., Zheng L; School of Biology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu, 215500, China.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Jun; Vol. 21 (6), pp. e202400152. Date of Electronic Publication: 2024 May 07.
DOI: 10.1002/cbdv.202400152
Abstrakt: Thromboembolism is the culprit of cardiovascular diseases, leading to the highest global mortality rate. Anticoagulation emerges as the primary approach for managing thrombotic conditions. Notably, sulfated polysaccharides exhibit favorable anticoagulant efficacy with reduced side effects. This review focuses on the structure-anticoagulant activity relationship of sulfated polysaccharides and the underlying action mechanisms. It is concluded that chlorosulfonicacid-pyridine method serves as the preferred technique to synthesize sulfated polysaccharides. The anticoagulant activity of sulfated polysaccharides is linked to the substitution site of sulfate groups, degree of substitution, molecular weight, main side chain structure, and glycosidic bond conformation. Moreover, sulfated polysaccharides exert anticoagulant activity via various pathways, including the inhibition of blood coagulation factors, activation of antithrombin III and heparin cofactor II, antiplatelet aggregation, and promotion of the fibrinolytic system.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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