Ultrasound-guided stellate ganglion block benefits the postoperative recovery of patients undergoing laparoscopic colorectal surgery: a single-center, double-blinded, randomized controlled clinical trial.

Autor: Lu DH; Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, No.58 2nd Zhongshan Road, Guangzhou, Guangdong, 510080, P.R. China., Xu XX; Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, No.58 2nd Zhongshan Road, Guangzhou, Guangdong, 510080, P.R. China., Zhou R; Department of Hepatobiliary Surgery, The Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang West Road, Guangzhou, Guangdong, 510120, P.R. China., Wang C; Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, No.58 2nd Zhongshan Road, Guangzhou, Guangdong, 510080, P.R. China., Lan LT; Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, No.58 2nd Zhongshan Road, Guangzhou, Guangdong, 510080, P.R. China., Yang XY; Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, No.58 2nd Zhongshan Road, Guangzhou, Guangdong, 510080, P.R. China. wooyoung@163.com., Feng X; Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, No.58 2nd Zhongshan Road, Guangzhou, Guangdong, 510080, P.R. China. fengxia@mail.sysu.edu.cn.
Jazyk: angličtina
Zdroj: BMC anesthesiology [BMC Anesthesiol] 2024 Apr 10; Vol. 24 (1), pp. 137. Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1186/s12871-024-02518-5
Abstrakt: Background: With the increasing prevalence of colorectal cancer (CRC), optimizing perioperative management is of paramount importance. This study investigates the potential of stellate ganglion block (SGB), known for its stress response-mediating effects, in improving postoperative recovery. We postulate that preoperative SGB may enhance the postoperative recovery of patients undergoing laparoscopic CRC surgery.
Methods: We conducted a randomized controlled trial of 57 patients undergoing laparoscopic colorectal cancer surgery at a single center. Patients, aged 18-70 years, were randomly assigned to receive either preoperative SGB or standard care. SGB group patients received 10 mL of 0.2% ropivacaine under ultrasound guidance prior to surgery. Primary outcome was time to flatus, with secondary outcomes encompassing time to defecation, lying in bed time, visual analog scale (VAS) pain score, hospital stays, patient costs, intraoperative and postoperative complications, and 3-year mortality. A per-protocol analysis was used.
Results: Twenty-nine patients in the SGB group and 28 patients in the control group were analyzed. The SGB group exhibited a significantly shorter time to flatus (mean [SD] hour, 20.52 [9.18] vs. 27.93 [11.69]; p = 0.012), accompanied by decreased plasma cortisol levels (mean [SD], postoperatively, 4.01 [3.42] vs 7.75 [3.13], p = 0.02). Notably, postoperative pain was effectively managed, evident by lower VAS scores at 6 h post-surgery in SGB-treated patients (mean [SD], 4.70 [0.91] vs 5.35 [1.32]; p = 0.040). Furthermore, patients in the SGB group experienced reduced hospital stay length (mean [SD], day, 6.61 [1.57] vs 8.72 [5.13], p = 0.042).
Conclusions: Preoperative SGB emerges as a promising approach to enhance the postoperative recovery of patients undergoing laparoscopic CRC surgery.
Clinical Trial Registration: ChiCTR1900028404, Principal investigator: Xia Feng, Date of registration: 12/20/2019.
(© 2024. The Author(s).)
Databáze: MEDLINE
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