Blood groups and Rhesus status as potential predictors of outcomes in patients with cardiac resynchronisation therapy.

Autor: Papageorgiou N; Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London, UK.; Institute of Cardiovascular Science, University College London, London, UK., Sohrabi C; Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London, UK., Bakogiannis C; 3rd Cardiology Department, AUTH, Ippokrateio Hospital, Thessaloniki, Greece., Tsarouchas A; 3rd Cardiology Department, AUTH, Ippokrateio Hospital, Thessaloniki, Greece., Kukendrarajah K; The Farr Institute of Health Informatics Research, University College London, London, UK., Matiti L; Broomfield Hospital, Mid and South Essex NHS Foundation Trust, Essex, UK., Srinivasan NT; Department of Cardiac Electrophysiology, Essex Cardiothoracic Centre, Basildon, UK.; Circulatory Health Research Group, Medical Technology Research Centre, School of Medicine, Anglia Ruskin University, Chelmsford, UK., Ahsan S; Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London, UK., Sporton S; Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London, UK., Schilling RJ; Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London, UK., Hunter RJ; Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London, UK., Muthumala A; Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London, UK., Creta A; Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London, UK., Chow AW; Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London, UK., Providencia R; Electrophysiology Department, Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, London, UK. r.providencia@ucl.ac.uk.; Institute of Cardiovascular Science, University College London, London, UK. r.providencia@ucl.ac.uk.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Apr 10; Vol. 14 (1), pp. 8371. Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1038/s41598-024-58747-8
Abstrakt: Cardiac resynchronisation therapy (CRT) improves prognosis in patients with heart failure (HF) however the role of ABO blood groups and Rhesus factor are poorly understood. We hypothesise that blood groups may influence clinical and survival outcomes in HF patients undergoing CRT. A total of 499 patients with HF who fulfilled the criteria for CRT implantation were included. Primary outcome of all-cause mortality and/or heart transplant/left ventricular assist device was assessed over a median follow-up of 4.6 years (IQR 2.3-7.5). Online repositories were searched to provide biological context to the identified associations. Patients were divided into blood (O, A, B, and AB) and Rhesus factor (Rh-positive and Rh-negative) groups. Mean patient age was 66.4 ± 12.8 years with a left ventricular ejection fraction of 29 ± 11%. There were no baseline differences in age, gender, and cardioprotective medication. In a Cox proportional hazard multivariate model, only Rh-negative blood group was associated with a significant survival benefit (HR 0.68 [0.47-0.98], p = 0.040). No association was observed for the ABO blood group (HR 0.97 [0.76-1.23], p = 0.778). No significant interaction was observed with prevention, disease aetiology, and presence of defibrillator. Rhesus-related genes were associated with erythrocyte and platelet function, and cholesterol and glycated haemoglobin levels. Four drugs under development targeting RHD were identified (Rozrolimupab, Roledumab, Atorolimumab, and Morolimumab). Rhesus blood type was associated with better survival in HF patients with CRT. Further research into Rhesus-associated pathways and related drugs, namely whether there is a cardiac signal, is required.
(© 2024. The Author(s).)
Databáze: MEDLINE
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