The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus.

Autor: Langedijk AC; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Lundlaan 6, 3584 EA, Utrecht, the Netherlands., Vrancken B; Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Herestraat 49, 3000, Leuven, Belgium.; Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Bruxelles, Belgium., Lebbink RJ; Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands., Wilkins D; Translational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, 1 MedImmune Way, Gaithersburg, MD, USA., Kelly EJ; Translational Medicine, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, 1 MedImmune Way, Gaithersburg, MD, USA., Baraldi E; Department of Woman's and Child's Health, University Hospital of Padova, Padova, Italy.; ReSViNET Foundation, Zeist, the Netherlands.; Institute of Pediatric Research 'Città della Speranza', Padova, Italy., Mascareñas de Los Santos AH; Jose Eluterio Gonzalez Hospital Universitario, Monterrey, Mexico., Danilenko DM; Smorodintsev Research Institute of Influenza, St. Petersburg, Russia., Choi EH; Seoul National University Children's Hospital, Seoul, South Korea., Palomino MA; Hospital Roberto del Río, Universidad de Chile, Santiago, Chile., Chi H; MacKay Children's Hospital, New Taipei, Taiwan, ROC., Keller C; Institute of Virology, University Hospital Giessen and Marburg, Marburg, Germany., Cohen R; Université Paris XII, Créteil, France., Papenburg J; McGill University Health Centre, Montreal, QC, Canada., Pernica J; McMaster University, Hamilton, ON, Canada., Greenough A; ReSViNET Foundation, Zeist, the Netherlands.; King's College London, London, UK., Richmond P; University of Western Australia, Perth, WA, Australia., Martinón-Torres F; ReSViNET Foundation, Zeist, the Netherlands.; Hospital Clínico Universitario de Santiago, Galicia, Spain., Heikkinen T; ReSViNET Foundation, Zeist, the Netherlands.; University of Turku and Turku University Hospital, Turku, Finland., Stein RT; ReSViNET Foundation, Zeist, the Netherlands.; Pontificia Universidade Catolica de Rio Grande do Sul, Porto Alegre, Brazil., Hosoya M; Fukushima Medical University School of Medicine, Fukushima, Japan., Nunes MC; ReSViNET Foundation, Zeist, the Netherlands.; Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; South African Medical Research Council, Vaccines & Infectious Diseases Analytics Research Unit, and Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Verwey C; Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Hospices Civils de Lyon and the Centre International de Recherche en Infectiologie (CIRI) Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France., Evers A; Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands., Kragten-Tabatabaie L; ReSViNET Foundation, Zeist, the Netherlands., Suchard MA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.; Department of Biostatistics, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA, 90095, USA.; Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Kosakovsky Pond SL; Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, 801 N Broad St, Philadelphia, PA, 19122, USA., Poletto C; INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique IPLESP, F75012, Paris, France., Colizza V; INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique IPLESP, F75012, Paris, France., Lemey P; Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Herestraat 49, 3000, Leuven, Belgium., Bont LJ; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Lundlaan 6, 3584 EA, Utrecht, the Netherlands. l.bont@umcutrecht.nl.; ReSViNET Foundation, Zeist, the Netherlands. l.bont@umcutrecht.nl.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Apr 10; Vol. 15 (1), pp. 3083. Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1038/s41467-024-47118-6
Abstrakt: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread.
(© 2024. The Author(s).)
Databáze: MEDLINE
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