An Autopsy Case of Antineutrophil Cytoplasmic Antibody-associated Vasculitis Induced by Propylthiouracil.

Autor:	Fujii G; Division of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Japan., Yoshihara R; Division of Rheumatology, Hyogo Prefectural Kakogawa Medical Center, Japan., Hyodo T; Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Japan., Ishida I; Division of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Japan., Onishi R; Division of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Japan., Fujimoto M; Division of Pathology, Hyogo Prefectural Kakogawa Medical Center, Japan., Iida K; Division of Diabetes and Endocrinology, Hyogo Prefectural Kakogawa Medical Center, Japan.
Jazyk:	angličtina
Zdroj:	Internal medicine (Tokyo, Japan) [Intern Med] 2024 Dec 01; Vol. 63 (23), pp. 3197-3202. Date of Electronic Publication: 2024 Apr 09.
DOI:	10.2169/internalmedicine.3397-23
Abstrakt:	Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a complication caused by antithyroid drugs, particularly propylthiouracil (PTU). Most patients experience organ failure due to the affects of the treatment regimen. We herein report the case of an 89-year-old woman whose severe AAV induced by PTU resulted in various instances of organ failure that eventually led to death after 9 years of PTU therapy. During autopsy, we identified five types of organ failure. As AAV is a potentially fatal disease, the development of various vasculitis symptoms during PTU therapy should therefore be carefully monitored.
Databáze:	MEDLINE
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