Influence of vitamin D supplementation on growth, body composition, pubertal development and spirometry in South African schoolchildren: a randomised controlled trial (ViDiKids).

Autor: Middelkoop K; Desmond Tutu HIV Centre, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Medicine, University of Cape Town, Cape Town, South Africa., Micklesfield L; Health through Physical Activity, Lifestyle and Sport Research Centre (HPALS), Department of Human Biology, Faculty of Health Sciences University of Cape Town, Cape Town, South Africa.; SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences University of the Witwatersrand, Johannesburg, South Africa., Stewart J; Desmond Tutu HIV Centre, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Medicine, University of Cape Town, Cape Town, South Africa., Walker N; Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Jolliffe DA; Blizard Institiute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Mendham AE; Health through Physical Activity, Lifestyle and Sport Research Centre (HPALS), Department of Human Biology, Faculty of Health Sciences University of Cape Town, Cape Town, South Africa.; SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences University of the Witwatersrand, Johannesburg, South Africa., Coussens AK; Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences University of Cape Town, Cape Town, South Africa.; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia., Nuttall J; Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa., Tang J; Norwich Medical School, University of East Anglia, Norwich, UK.; Department of Laboratory Medicine, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK., Fraser WD; Norwich Medical School, University of East Anglia, Norwich, UK.; Department of Laboratory Medicine, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK., Momand W; Blizard Institiute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Cooper C; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; University Hospital Southampton NHS Foundation Trust, Southampton, UK., Harvey NC; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; University Hospital Southampton NHS Foundation Trust, Southampton, UK., Wilkinson RJ; Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences University of Cape Town, Cape Town, South Africa.; The Francis Crick Institute, London, UK.; Department of Infectious Diseases, Imperial College London, London, UK., Bekker LG; Desmond Tutu HIV Centre, Institute of Infectious Disease & Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Department of Medicine, University of Cape Town, Cape Town, South Africa., Martineau AR; Blizard Institiute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK a.martineau@qmul.ac.uk.
Jazyk: angličtina
Zdroj: BMJ paediatrics open [BMJ Paediatr Open] 2024 Apr 10; Vol. 8 (1). Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1136/bmjpo-2024-002495
Abstrakt: Objective: To determine whether weekly oral vitamin D supplementation influences growth, body composition, pubertal development or spirometric outcomes in South African schoolchildren.
Design: Phase 3 double-blind randomised placebo-controlled trial.
Setting: Socioeconomically disadvantaged peri-urban district of Cape Town, South Africa.
Participants: 1682 children of black African ancestry attending government primary schools and aged 6-11 years at baseline.
Interventions: Oral vitamin D 3 (10 000 IU/week) versus placebo for 3 years.
Main Outcome Measures: Height-for-age and body mass index-for-age, measured in all participants; Tanner scores for pubertal development, spirometric lung volumes and body composition, measured in a subset of 450 children who additionally took part in a nested substudy.
Results: Mean serum 25-hydroxyvitamin D 3 concentration at 3-year follow-up was higher among children randomised to receive vitamin D versus placebo (104.3 vs 64.7 nmol/L, respectively; mean difference (MD) 39.7 nmol/L, 95% CI 37.6 to 41.9 nmol/L). No statistically significant differences in height-for-age z-score (adjusted MD (aMD) -0.08, 95% CI -0.19 to 0.03) or body mass index-for-age z-score (aMD -0.04, 95% CI -0.16 to 0.07) were seen between vitamin D versus placebo groups at follow-up. Among substudy participants, allocation to vitamin D versus placebo did not influence pubertal development scores, % predicted forced expiratory volume in 1 s (FEV1), % predicted forced vital capacity (FVC), % predicted FEV1/FVC, fat mass or fat-free mass.
Conclusions: Weekly oral administration of 10 000 IU vitamin D 3 boosted vitamin D status but did not influence growth, body composition, pubertal development or spirometric outcomes in South African schoolchildren.
Trial Registration Numbers: ClinicalTrials.gov NCT02880982, South African National Clinical Trials Register DOH-27-0916-5527.
Competing Interests: Competing interests: None.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
Databáze: MEDLINE
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