Assessment of Human Fetuses Undergoing Acute Pain: Validation of the Fetal-7 Scale.

Autor:	Bernardes LS; Center for Clinical Research, North Denmark Regional Hospital, Hjoerring, Denmark; Gynecology and Obstetrics Department, University of Sao Paulo, São Paulo, Brazil; Gynecology and obstetrics, SEPACO Maternity Hospital, São Paulo, Brazil; Department of Gynecology and Obstetrics, North Denmark Regional Hospital, Hjoerring, Denmark. Electronic address: l.bernardes@rn.dk., Fernandes AM; Pain Center, Department of Neurology, University of Sao Paulo, São Paulo, Brazil., Carvalho MA; Gynecology and Obstetrics Department, University of Sao Paulo, São Paulo, Brazil; Gynecology and obstetrics, SEPACO Maternity Hospital, São Paulo, Brazil., Ottolia J; Gynecology and Obstetrics Department, University of Sao Paulo, São Paulo, Brazil; Gynecology and obstetrics, SEPACO Maternity Hospital, São Paulo, Brazil., Hamani M; Pain Center, Department of Neurology, University of Sao Paulo, São Paulo, Brazil., Oliveira I; Pain Center, Department of Neurology, University of Sao Paulo, São Paulo, Brazil., Kubota GT; Pain Center, Department of Neurology, University of Sao Paulo, São Paulo, Brazil., da Silva VA; Pain Center, Department of Neurology, University of Sao Paulo, São Paulo, Brazil., Veloso A; Computational Science Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., de Carvalho MHB; Gynecology and Obstetrics Department, University of Sao Paulo, São Paulo, Brazil., de Amorim Filho AG; Gynecology and Obstetrics Department, University of Sao Paulo, São Paulo, Brazil., Arenholt LTS; Center for Clinical Research, North Denmark Regional Hospital, Hjoerring, Denmark; Department of Gynecology and Obstetrics, North Denmark Regional Hospital, Hjoerring, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Leutscher PC; Center for Clinical Research, North Denmark Regional Hospital, Hjoerring, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., de Andrade DC; Center for Neuroplasticity and Pain, Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark; Pain Center, Department of Neurology, University of Sao Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	The journal of pain [J Pain] 2024 Sep; Vol. 25 (9), pp. 104527. Date of Electronic Publication: 2024 Apr 08.
DOI:	10.1016/j.jpain.2024.104527
Abstrakt:	Improvements in fetal ultrasound have allowed for the diagnosis and treatment of fetal diseases in the uterus, often through surgery. However, little attention has been drawn to the assessment of fetal pain. To address this gap, a fetal pain scoring system, known as the Fetal-7 scale, was developed. The present study is a full validation of the Fetal-7 scale. The validation involved 2 steps: 1) 4 fetuses with the indication of surgery were evaluated in 3 conditions perioperatively: acute pain, rest, and under loud sound stimulation. Facial expressions were assessed by 30 raters using screenshots from 4D high-definition ultrasound films; 2) assessment of sensitivity and specificity of the Fetal-7 scale in 54 healthy fetuses and 2 fetuses undergoing acute pain after preoperative anesthetic intramuscular injection. There was high internal consistency with Cronbach's alpha (α) of .99. Intrarater reliability of the Fetal-7 scale (test-retest) calculated by intraclass correlation coefficient was .95, and inter-rater reliability was .99. The scale accurately differentiated between healthy fetuses at rest and those experiencing acute pain (sensitivity of 100% and specificity of 94.4%). The Fetal-7 scale is a valid tool for assessing acute pain-related behavior in third-trimester fetuses and may be of value in guiding analgesic procedures efficacy in these patients. Further research is warranted to explore the presence of postoperative pain in fetuses and its effects after birth. PERSPECTIVE: Recordings with 3-dimensional ultrasound of human fetuses undergoing preoperative anesthetic injections revealed complex facial expressions during acute pain, similar to those collected in newborns. This study presented the validation process and cut-off value of the Fetal-7 scale, paving the way for the study of pain before birth in humans. (Copyright © 2024 United States Association for the Study of Pain, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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