Metabolic adaptations in cancer stem cells: A key to therapy resistance.

Autor: Masoudi M; School of Medicine and Dentistry, Griffith University, Gold Coast 4222, Australia., Moti D; School of Medicine and Dentistry, Griffith University, Gold Coast 4222, Australia., Masoudi R; Faculty of Science, The University of British Columbia, Vancouver, British Columbia, Canada., Auwal A; Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh., Hossain MM; Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh., Pronoy TUH; Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh., Rashel KM; Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh., Gopalan V; School of Medicine and Dentistry, Griffith University, Gold Coast 4222, Australia., Islam F; Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh. Electronic address: farhad_bio83@ru.ac.bd.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Jun; Vol. 1870 (5), pp. 167164. Date of Electronic Publication: 2024 Apr 09.
DOI: 10.1016/j.bbadis.2024.167164
Abstrakt: Cancer stem cells (CSCs) are a subset of tumor cells that can initiate and sustain tumor growth and cause recurrence and metastasis. CSCs are particularly resistant to conventional therapies compared to their counterparts, owing greatly to their intrinsic metabolic plasticity. Metabolic plasticity allows CSCs to switch between different energy production and usage pathways based on environmental and extrinsic factors, including conditions imposed by conventional cancer therapies. To cope with nutrient deprivation and therapeutic stress, CSCs can transpose between glycolysis and oxidative phosphorylation (OXPHOS) metabolism. The mechanism behind the metabolic pathway switch in CSCs is not fully understood, however, some evidence suggests that the tumor microenvironment (TME) may play an influential role mediated by its release of signals, such as Wnt/β-catenin and Notch pathways, as well as a background of hypoxia. Exploring the factors that promote metabolic plasticity in CSCs offers the possibility of eventually developing therapies that may more effectively eliminate the crucial tumor cell subtype and alter the disease course substantially.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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