[Penile cancer with perineural invasion is more prone to postoperative recurrence].

Autor:	Han YF; Department of Urology, Yuebei People`s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, Guangdong 512026, China., Yao XH; Department of Cardiovascular Medicine, Yuebei People`s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, Guangdong 512026, China.., Deng JW; Department of Urology, Yuebei People`s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, Guangdong 512026, China., Lai B; Department of Urology, Yuebei People`s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, Guangdong 512026, China., Zeng YM; Department of Urology, Yuebei People`s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, Guangdong 512026, China., Peng L; Department of Urology, Yuebei People`s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, Guangdong 512026, China., Tang ZJ; Department of Urology, Yuebei People`s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, Guangdong 512026, China., Wang C; Department of Urology, Yuebei People`s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, Guangdong 512026, China., Li JW; Department of Urology, Yuebei People`s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, Guangdong 512026, China.
Jazyk:	čínština
Zdroj:	Zhonghua nan ke xue = National journal of andrology [Zhonghua Nan Ke Xue] 2023 Apr; Vol. 29 (4), pp. 337-341.
Abstrakt:	Objective: To explore the correlation between perineural invasion and postoperative recurrence in patients surgically treated for penile cancer. Methods: We conducted a retrospective analysis of the clinical data on 18 penile cancer patients surgically treated in our hospital from January 2018 to December 2021, 8 with postoperative recurrence (the recurrence group) and the other 10 without (the non-recurrence control group). We compared the two groups of patients in the age of onset, tumor-node-metastasis (TNM) stages, American Joint Committee on Cancer (AJCC) prognosis stages, surgical methods, perineural invasion and recurrence time. We analyzed the differences in postoperative recurrence using the Kaplan Meier plotted survival curve and in independent risk factors in predicting postoperative recurrence using the ROC curve. Results: Compared with the non-recurrence controls, the patients in the recurrence group had a significantly older age of onset (P=0.0411) and severer perineural invasion (P<0.001), and those with perineural invasion had a shorter recurrence time (P<0.001), which was an independent risk factor for postoperative recurrence. The areas under the ROC curves for perineural invasion and age were 0.885 and 0.213, respectively. Conclusion: Penile cancer with perineural invasion is more prone to and perineural invasion is an independent risk factor for postoperative recurrence of the malignancy.
Databáze:	MEDLINE
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