Is there a link between appendicitis and the risk of diverticular disease?: a large German cohort study.

Autor: Krieg S; Department of Inclusive Medicine, University Hospital Ostwestfalen-Lippe, Bielefeld University, 33617, Bielefeld, Germany., Kolbe EW; Department of General and Visceral Surgery, Thoracic Surgery and Proctology, Medical Campus OWL, University Hospital Herford, Ruhr University Bochum, 32049, Herford, Germany., Loosen SH; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, 40225, Duesseldorf, Germany., Roderburg C; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, 40225, Duesseldorf, Germany., Krieg A; Department of General and Visceral Surgery, Thoracic Surgery and Proctology, Medical Campus OWL, University Hospital Herford, Ruhr University Bochum, 32049, Herford, Germany. andreas.krieg@ruhr-uni-bochum.de., Kostev K; IQVIA, 60549, Frankfurt, Germany.
Jazyk: angličtina
Zdroj: International journal of colorectal disease [Int J Colorectal Dis] 2024 Apr 10; Vol. 39 (1), pp. 50. Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1007/s00384-024-04624-9
Abstrakt: Purpose: Appendicitis, characterized by inflammation of the vermiform appendix, is a common abdominal emergency necessitating appendectomy. Recent evidence suggests a potential link between appendicitis and subsequent diverticular disease, yet population-based studies investigating this association are limited.
Methods: Utilizing the Disease Analyzer database encompassing data from over 1000 primary care practices in Germany, we conducted a retrospective cohort study. We included 25,379 adults diagnosed with appendicitis and an equal number of matched controls without appendicitis. The incidence of diverticular disease over a 10-year follow-up period was compared between the two cohorts. Cox regression analysis was performed to assess the association between appendicitis and diverticular disease, adjusting for potential confounders.
Results: Our findings revealed a significant association between appendicitis and subsequent diverticular disease (HR: 1.76; 95% CI: 1.57-1.97), with an increased risk observed across all age groups. Notably, this association was stronger in men (HR: 2.00; 95% CI: 1.68-2.37) than in women (HR: 1.58; 95% CI: 1.36-1.84). The cumulative 10-year incidence of diverticular disease was higher in patients with appendicitis (6.5%) compared to those without (3.6%). Additionally, we observed a clear age-dependent increase in the incidence of diverticular disease.
Conclusion: This large-scale population-based study provides valuable insights into the interaction between appendicitis and diverticular disease. The study underscores the need for further research elucidating the underlying mechanisms linking appendicitis to diverticular disease. Probiotics emerge as a potential therapeutic avenue warranting exploration in the management of both conditions. These findings have important implications for clinical practice, highlighting the importance of considering appendicitis as a potential risk factor for diverticular disease, particularly in men. Further investigation is warranted to validate these findings and explore potential therapeutic interventions targeting the shared pathophysiological pathways underlying both conditions.
(© 2024. The Author(s).)
Databáze: MEDLINE
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