The plasma proteome is linked with left ventricular and left atrial function parameters in patients with chronic heart failure.

Autor:	Abou Kamar S; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands.; The Netherlands Heart Institute, Moreelsepark 1, 3511 EP Utrecht, The Netherlands.; Department of Cardiology, Franciscus Gasthuis & Vlietland, Kleiweg 500, 3045 PM Rotterdam, The Netherlands., Andrzejczyk K; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands., Petersen TB; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands.; Department of Biostatistics, University Medical Center Rotterdam, Erasmus University, Dr. Molewaterplein 40, 3000 CA Rotterdam, The Netherlands., Chin JF; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands.; Department of Cardiology, Franciscus Gasthuis & Vlietland, Kleiweg 500, 3045 PM Rotterdam, The Netherlands., Aga YS; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands.; Department of Cardiology, Franciscus Gasthuis & Vlietland, Kleiweg 500, 3045 PM Rotterdam, The Netherlands., de Bakker M; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands., Akkerhuis KM; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands., Geleijnse M; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands., Brugts JJ; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands., Sorop O; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands., de Boer RA; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands., Rizopoulos D; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands.; Department of Biostatistics, University Medical Center Rotterdam, Erasmus University, Dr. Molewaterplein 40, 3000 CA Rotterdam, The Netherlands., Asselbergs FW; Department of Cardiology, Amsterdam Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands., Boersma E; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands., den Ruijter H; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands., van Dalen BM; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands.; Department of Cardiology, Franciscus Gasthuis & Vlietland, Kleiweg 500, 3045 PM Rotterdam, The Netherlands., Kardys I; Department of Cardiology, Erasmus MC, Thorax Center, Cardiovascular Institute, University Medical Center Rotterdam, Room Na-316, PO Box 2040 3000 CA Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2024 Aug 26; Vol. 25 (9), pp. 1206-1215.
DOI:	10.1093/ehjci/jeae098
Abstrakt:	Aims: Examining the systemic biological processes in the heterogeneous syndrome of heart failure with reduced ejection fraction (HFrEF), as reflected by circulating proteins, in relation to echocardiographic characteristics, may provide insights into heart failure pathophysiology. We investigated the link of 4210 repeatedly measured circulating proteins with repeatedly measured echocardiographic parameters as well as with elevated left atrial pressure (LAP), in patients with HFrEF, to provide insights into underlying mechanisms. Methods and Results: In 173 patients with HFrEF, we performed 6-monthly echocardiography and trimonthly blood sampling during a median follow-up of 2.7 (inter-quartile range: 2.5-2.8) years. We investigated circulating proteins in relation to echocardiographic parameters of left ventricular [left ventricular ejection fraction (LVEF), global longitudinal strain (GLS)] and left atrial function [left atrial reservoir strain (LASr)] and elevated LAP (E/e' ratio >15) and used gene enrichment analyses to identify underlying pathophysiological processes. We found 723, 249, 792, and 427 repeatedly measured proteins, with significant associations with LVEF, GLS, LASr, and E/e' ratio, respectively. Proteins associated with LASr reflected pathophysiological mechanisms mostly related to the extracellular matrix. Proteins associated with GLS reflected cardiovascular biological processes and diseases, whereas those associated with LVEF reflected processes involved in the sympathetic nervous system. Moreover, 49 proteins were associated with elevated LAP; after correction for LVEF, three proteins remained: cystatin-D, fibulin-5, and HSP40. Conclusion: Circulating proteins show varying associations with different echocardiographic parameters in patients with HFrEF. These findings suggest that pathways involved in atrial and ventricular dysfunction, as reflected by the plasma proteome, are distinct. Competing Interests: Conflict of interest: J.J.B. received independent research grant from Abbott for ISS and has had speaker engagement or advisory boards in the past 5 years with Astra Zeneca, Abbott, Boehringer Ingelheim, Bayer, Daiichi Sankyo, Novartis, and Vifor. R.A.d.B. received research grants and/or fees from AstraZeneca, Abbott, Boehringer Ingelheim, Cardior Pharmaceuticals GmbH, Ionis Pharmaceuticals, Inc., Novo Nordisk, and Roche and has had speaker engagements with Abbott, AstraZeneca, Bayer, Bristol Myers Squibb, Novartis, and Roche. (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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