Evidence for intracellular Pseudomonas aeruginosa .
| Autor: | Resko ZJ; Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA., Suhi RF; Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA., Thota AV; Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA., Kroken AR; Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of bacteriology [J Bacteriol] 2024 May 23; Vol. 206 (5), pp. e0010924. Date of Electronic Publication: 2024 Apr 10. |
| DOI: | 10.1128/jb.00109-24 |
| Abstrakt: | Pseudomonas aeruginosa is a significant cause of global morbidity and mortality. Although it is often regarded as an extracellular pathogen toward human cells, numerous investigations report its ability to survive and replicate within host cells, and additional studies demonstrate specific mechanisms enabling it to adopt an intracellular lifestyle. This ability of P. aeruginosa remains less well-investigated than that of other intracellular bacteria, although it is currently gaining attention. If intracellular bacteria are not killed after entering host cells, they may instead receive protection from immune recognition and experience reduced exposure to antibiotic therapy, among additional potential advantages shared with other facultative intracellular pathogens. For this review, we compiled studies that observe intracellular P. aeruginosa across strains, cell types, and experimental systems in vitro , as well as contextualize these findings with the few studies that report similar observations in vivo . We also seek to address key findings that drove the perception that P. aeruginosa remains extracellular in order to reconcile what is currently understood about intracellular pathogenesis and highlight open questions regarding its contribution to disease. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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