| Autor: |
Abouzid M; Department of Physical Pharmacy & Pharmacokinetics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.; Doctoral School, Poznan University of Medical Sciences, 60-812 Poznan, Poland., Burchardt P; Department of Hypertension, Angiology, & Internal Medicine, Poznan University of Medical Sciences, 61-848 Poznan, Poland.; Department of Cardiology, J. Struś Hospital, 61-285 Poznan, Poland., Kagan L; Department of Pharmaceutics and Center of Excellence for Pharmaceutical Translational Research and Education, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA., Główka F; Department of Physical Pharmacy & Pharmacokinetics, Poznan University of Medical Sciences, 60-806 Poznan, Poland., Karaźniewicz-Łada M; Department of Physical Pharmacy & Pharmacokinetics, Poznan University of Medical Sciences, 60-806 Poznan, Poland. |
| Abstrakt: |
Aim: This work was designed to investigate the associations between vitamin D metabolites, VDR gene polymorphisms and echocardiographic markers in a population of patients with cardiovascular disease. Methods: Echocardiographic markers for 42 patients were determined with tissue Doppler techniques. PCR-restriction fragment length polymorphism analysis identified genetic variants ApaI , TaqI , BsmI and FokI . A validated UHPLC-MS/MS method determined vitamin D metabolites. Results: Patients with the ApaI -GT genotype exhibited a lower pressure gradient across the aortic valve than ApaI -TT carriers. BMI, ApaI -GT, TaqI -TC, aortic arch diameter and maximal pressure gradient were significant univariate predictors of hypertension. Conclusion: A potential link exists between VDR gene polymorphisms and cardiovascular function. |
