Comparison of Different Antibiotic Medications on Microorganisms: An Original Research.

Autor: Patil RS; Prosthodontics, Research Student Worker, Kornberg School of Dentistry, Temple University, Philadelphia, United States., Onteru P; Department of Public Health Dentistry, Father Colombo Institute of Medical Sciences, Warangal, Telangana, India., Jena J; Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, Odisha, India., Shashank C; Department of Radio-Diagnosis, Maheshwara Medical College, Hyderabad, Telangana, India., Siddiqua H; Consultant Dental Surgeon, Expert Dental Care, Hyderabad, Telangana, India., Parikh HA; Department of Periodontology, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India., Tiwari HD; Rashtriya Kishore Swasthya Karyakram Consultant, District Medical and Health Office, Visakhapatnam, Andhra Pradesh, India.
Jazyk: angličtina
Zdroj: Journal of pharmacy & bioallied sciences [J Pharm Bioallied Sci] 2024 Feb; Vol. 16 (Suppl 1), pp. S223-S226. Date of Electronic Publication: 2024 Feb 29.
DOI: 10.4103/jpbs.jpbs_471_23
Abstrakt: Introduction: The onset and maintenance of disease can be significantly influenced by the colonization of the mouth cavity by pathogenic microorganisms or by an imbalance of the physiological microbiome. Hence, in the current study, various commonly used antibiotics have been tested for their antibacterial and antifungal activity.
Materials and Methods: The current research was performed as an in vitro study. The commonly used antibiotics Augmentin (CV), Ceftriaxone-Cephalosporin (CF), and Linezolid were tested for the microorganisms, lactobacillus, and Escherichia coli . The "Radius of Zone of Inhibition (mm)- RZI" after 24 and 48 h were tested by the agar-well diffusion method.
Results: For E. coli , the antibiotics tested were CV (5 μl and 2.5 μl), CF (5 μl and 2.5 μl), and Linezolid (5 μl and 2.5 μl). The results showed that the radius of the zone of inhibition was consistent for each antibiotic concentration, with a range of 0.8-1.4 mm at both time points. For Lactobacillus, the antibiotics tested were CV (5 μl and 2.5 μl), CF (5 μl and 2.5 μl), and Linezolid (5 μl and 2.5 μl). The results showed that the radius of the zone of inhibition varied between antibiotics and concentrations, with a range of 0.5-1.8 mm at both time points.
Conclusion: This study highlights antibiotics' antibacterial action against E. coli and Lactobacillus. The data imply that antibiotic efficacy varied by organism and drug concentration. These organisms' antibiotic resistance mechanisms and new antibiotic resistance methods need more study.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2024 Journal of Pharmacy and Bioallied Sciences.)
Databáze: MEDLINE
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