Platelet-rich Plasma as Effectiveness in the Treatment of Osteoarthrosis of the Knee in a Tertiary Care Center.

Autor: Teja AM; Department of Orthopaedics, Sukh Sagar Medical College, Jabalpur, Madhya Pradesh, India., Kumar M; Department of Orthopaedics, Pacific Medical College and Hospital, Udaipur, Rajasthan, India., Shashank C; Department of Radio-Diagnosis, Maheshwara Medical College, Hyderabad, Telangana, India., Saifuddin R; Lithuanian University of Health Sciences, Kaunas, Lithuania, Europe., Tiwari RV; Consultant Oral and Maxillofacial Surgeon, OMNI and Andhra Hospitals, Visakhapatnam, Andhra Pradesh, India., Thakkar S; Shri M P Shah Government Medical College, Gujarat, India., Jasmine; Department of General Surgery, Gayatri Vidya Parishad Medical College and Hospital, Visakhapatam, Andhra Pradesh, India.
Jazyk: angličtina
Zdroj: Journal of pharmacy & bioallied sciences [J Pharm Bioallied Sci] 2024 Feb; Vol. 16 (Suppl 1), pp. S296-S298. Date of Electronic Publication: 2024 Feb 29.
DOI: 10.4103/jpbs.jpbs_499_23
Abstrakt: Introduction: Osteoarthrosis (OA) is a condition that develops slowly but eventually causes considerable morbidity. Many medical specialties have employed platelet-rich plasma (PRP) since it is the best autologous biological blood-derived product, can be exogenously supplied to tissues, and releases high concentrations of platelet-derived growth factors to promote tendon, bone, and wound healing. This prospective research aims to clinically assess the effectiveness of PRP injection therapy for treating knee osteoarthrosis.
Materials and Methods: A clinical prospective study was conducted at a tertiary care center for a period of a year. Subjects older than 50 years were selected for both genders who had a symptomatic primary knee OA. PRP is administered to and evaluated in 80 patients with knee osteoarthrosis. Using the VAS and WOMAC questionnaire tools, primary data was collected. The observations were compared using the appropriate statistical tools while considering significance at 95%.
Results: Eighty-four subjects participated in the study till the end of the study period of 3 months. All study participants filled out questionnaires before injection, eight weeks after injection, and 12 weeks after. The obtained scores for the WOMAC and the VAS were compared, and it was observed that after 12 weeks, the WOMAC scores lowered from 77 to 33 ( P < 0.001) and the VAS scores lowered to 6 to 1.5 ( P < 0.001) and these alterations were significant.
Conclusion: According to the most recent research, PRP therapy is a less expensive and more straightforward therapeutic option for the management of knee pain in patients who have OA, and it has also improved patients' ability to participate in everyday activities.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2024 Journal of Pharmacy and Bioallied Sciences.)
Databáze: MEDLINE
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