Association of adipokine levels with obesity in periodontal health and disease: A systematic review with meta-analysis and meta-regression.

Autor: Kandaswamy E; Department of Periodontics, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Lee CT; Department of Periodontics and Dental Hygiene, The University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas, USA., Gururaj SB; Department of Periodontics, Sharavathi Dental College and Hospital, Rajiv University of Health Sciences, Bangalore, Karnataka, India., Shivanaikar S; Department of Periodontology, Maratha Mandal's Nathajirao G Halgekar Institute of Dental Sciences and Research Centre, Belagavi, Karnataka, India., Joshi VM; Department of Periodontics, School of Dentistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Jazyk: angličtina
Zdroj: Journal of periodontal research [J Periodontal Res] 2024 Aug; Vol. 59 (4), pp. 623-635. Date of Electronic Publication: 2024 Apr 09.
DOI: 10.1111/jre.13263
Abstrakt: This study aimed to investigate the levels of serum, gingival crevicular fluid (GCF), and salivary adipokines and their possible relationship with periodontitis and obesity. An electronic search was conducted in the following databases: PubMed/ Medline, Scopus, and EBSCOhost through February 2023. Two independent reviewers screened the titles, abstracts, and full text of all the studies. Studies comparing the levels of adipokines in GCF, serum, and/or saliva in subjects with obesity and periodontitis (group 1), subjects with normal weight and periodontitis (group 2), and subjects with obesity and gingival health (group 3) were included. Meta-analyses and meta-regression were performed on the data from included studies. Seventeen studies with study participants ranging from 30 to 120 were included with subjects in each group ranging from 10 to 40. There was a significant increase in levels of serum TNF-α, leptin, IL-6, and CRP between groups 1 and 2 (p < .05). In GCF, TNF-α and resistin levels were significantly higher (p < .05) in Group 1 vs. 2. Serum level of leptin was higher for group 1 vs. 3 (p < .05). Meta-regression analysis revealed that the obesity definition (body mass index (BMI) cut-off value >25 or >30) was significant for serum resistin (p < .05) and GCF resistin (p < .05) between group 1 and 2. The current analysis indicates that both periodontitis and obesity can modulate the pro-inflammatory cytokines at systemic and local levels. This bidirectional interaction of periodontitis and obesity via the inflammation pathway seems likely plausible. Further studies are required to elucidate this mechanism in more detail.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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