Genetic and virological characteristics of a reassortant avian influenza A H6N1 virus isolated from wild birds at a live-bird market in Egypt.

Autor: Kutkat O; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt., Gomaa M; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt., Aboulhoda BE; Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt., Moatasim Y; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt., El Taweel A; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt., Kamel MN; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt., El Sayes M; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt., Elkhrsawy A; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt., AbdAllah H; Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt., Kandeil A; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt.; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., McKenzie PP; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Webby RJ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Ali MA; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt., Kayali G; Human Link, Dubai, United Arab Emirates. ghazi@human-link.org., El-Shesheny R; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, 12622, Egypt. rabeh.elshesheny@human-link.org.
Jazyk: angličtina
Zdroj: Archives of virology [Arch Virol] 2024 Apr 09; Vol. 169 (5), pp. 95. Date of Electronic Publication: 2024 Apr 09.
DOI: 10.1007/s00705-024-06022-6
Abstrakt: The first detection of a human infection with avian influenza A/H6N1 virus in Taiwan in 2013 has raised concerns about this virus. During our routine surveillance of avian influenza viruses (AIVs) in live-bird markets in Egypt, an H6N1 virus was isolated from a garganey duck and was characterized. Phylogenetic analysis indicated that the Egyptian H6N1 strain A/Garganey/Egypt/20869C/2022(H6N1) has a unique genomic constellation, with gene segments inherited from different subtypes (H5N1, H3N8, H7N3, H6N1, and H10N1) that have been detected previously in AIVs from Egypt and some Eurasian countries. We examined the replication of kinetics of this virus in different mammalian cell lines (A549, MDCK, and Vero cells) and compared its pathogenicity to that of the ancestral H6N1 virus A/Quail/HK/421/2002(H6N1). The Egyptian H6N1 virus replicated efficiently in C57BL/6 mice without prior adaptation and grew faster and reached higher titers than in A549 cells than the ancestral strain. These results show that reassortant H6 AIVs might pose a potential threat to human health and highlight the need to continue surveillance of H6 AIVs circulating in nature.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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