High vs low CPAP strategy with aerosolized calfactant in preterm infants with respiratory distress syndrome.

Autor: Kaluarachchi DC; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA. kaluarachchi@pediatrics.wisc.edu., Gerday E; Utah Valley Hospital, Provo, UT and Department of Pediatrics, University of Utah, Salt Lake City, UT, USA., Bahr T; Utah Valley Hospital, Provo, UT and Department of Pediatrics, University of Utah, Salt Lake City, UT, USA., Zapata HA; Department of Pediatrics, Division of Neonatology, University of Florida School of Medicine -Jacksonville, Jacksonville, FL, USA., Lasarev MR; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA., Guthrie SO; Department of Pediatrics, Division of Neonatology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Jackson-Madison County General Hospital, Jackson, TN, USA., Minton S; Utah Valley Hospital, Provo, UT and Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Apr 09. Date of Electronic Publication: 2024 Apr 09.
DOI: 10.1038/s41372-024-01959-7
Abstrakt: Background: Optimal CPAP strategy to prevent CPAP failure defined as need for endotracheal intubation is unknown.
Objective: To evaluate the risk of CPAP failure in infants treated with high vs low CPAP strategy while receiving aerosolized calfactant in the AERO-02 clinical trial and AERO-03 expanded access program.
Methods: Infants born between 29 0/7 to 36 6/7 weeks were included. Comparisons were made between low and high CPAP groups (Low, 4-7 cm H 2 O; High, 8-10 cm H 2 O).
Results: CPAP failure and pneumothorax were not different between the groups. Odds of CPAP failure were not different after adjustment for baseline characteristics (OR = 0.61; 95% CI: 0.29, 1.24).
Conclusion: We found no difference in CPAP failure among infants who received aerosolized calfactant that were treated with high vs low CPAP strategy. Efficacy of high CPAP strategy with aerosolized surfactant treatment needs to be evaluated in future studies.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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