A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration.

Autor: Weiler S; Sainsbury Wellcome Centre for Neuronal Circuits and Behaviour, University College London, 25 Howland Street, London, W1T 4JG, UK., Rahmati V; Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747, Jena, Germany., Isstas M; Friedrich Schiller University Jena, Institute of General Zoology and Animal Physiology, Erbertstraße 1, 07743, Jena, Germany., Wutke J; Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747, Jena, Germany., Stark AW; Friedrich Schiller University Jena, Institute of Applied Optics and Biophysics, Fröbelstieg 1, 07743, Jena, Germany., Franke C; Friedrich Schiller University Jena, Institute of Applied Optics and Biophysics, Fröbelstieg 1, 07743, Jena, Germany.; Friedrich Schiller University Jena, Jena Center for Soft Matter, Philosophenweg 7, 07743, Jena, Germany.; Friedrich Schiller University Jena, Abbe Center of Photonics, Albert-Einstein-Straße 6, 07745, Jena, Germany., Graf J; Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747, Jena, Germany., Geis C; Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747, Jena, Germany., Witte OW; Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747, Jena, Germany., Hübener M; Max Planck Institute for Biological Intelligence, Am Klopferspitz 18, 82152, Martinsried, Germany., Bolz J; Friedrich Schiller University Jena, Institute of General Zoology and Animal Physiology, Erbertstraße 1, 07743, Jena, Germany., Margrie TW; Sainsbury Wellcome Centre for Neuronal Circuits and Behaviour, University College London, 25 Howland Street, London, W1T 4JG, UK., Holthoff K; Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747, Jena, Germany., Teichert M; Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747, Jena, Germany. manuel.teichert@med.uni-jena.de.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Apr 10; Vol. 15 (1), pp. 3081. Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1038/s41467-024-47459-2
Abstrakt: Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems combine such information. Here in mice, we used a combination of stereo photogrammetry for 3D reconstruction of the whisker array, brain-wide anatomical tracing and functional connectivity analysis to explore the possibility of tacto-visual convergence in sensory space and within the circuitry of the primary visual cortex (VISp). Strikingly, we find that stimulation of the contralateral whisker array suppresses visually evoked activity in a tacto-visual sub-region of VISp whose visual space representation closely overlaps with the whisker search space. This suppression is mediated by local fast-spiking interneurons that receive a direct cortico-cortical input predominantly from layer 6 neurons located in the posterior primary somatosensory barrel cortex (SSp-bfd). These data demonstrate functional convergence within and between two primary sensory cortical areas for multisensory object detection and recognition.
(© 2024. The Author(s).)
Databáze: MEDLINE
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