Luminescent Supramolecular Metallogels: Drug Loading and Eu(III) as Structural Probe.

Autor: Freire RVM; Department of Fundamental Chemistry, Federal University of Pernambuco, Cidade Universitária, 50740-560, Recife, Brazil., Coelho DMA; Department of Fundamental Chemistry, Federal University of Pernambuco, Cidade Universitária, 50740-560, Recife, Brazil., Maciel LG; Department of Fundamental Chemistry, Federal University of Pernambuco, Cidade Universitária, 50740-560, Recife, Brazil., Jesus LT; Department of Fundamental Chemistry, Federal University of Pernambuco, Cidade Universitária, 50740-560, Recife, Brazil.; Pople Computational Chemistry Laboratory, Department of Chemistry, Federal University of Sergipe, 49107-230, São Cristóvão, SE, Brazil., Freire RO; Pople Computational Chemistry Laboratory, Department of Chemistry, Federal University of Sergipe, 49107-230, São Cristóvão, SE, Brazil., Dos Anjos JV; Department of Fundamental Chemistry, Federal University of Pernambuco, Cidade Universitária, 50740-560, Recife, Brazil., Junior SA; Department of Fundamental Chemistry, Federal University of Pernambuco, Cidade Universitária, 50740-560, Recife, Brazil.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Jun 12; Vol. 30 (33), pp. e202400680. Date of Electronic Publication: 2024 May 03.
DOI: 10.1002/chem.202400680
Abstrakt: Supramolecular metallogels combine the rheological properties of gels with the color, magnetism, and other properties of metal ions. Lanthanide ions such as Eu(III) can be valuable components of metallogels due to their fascinating luminescence. In this work, we combine Eu(III) and iminodiacetic acid (IDA) into luminescent hydrogels. We investigate the tailoring of the rheological properties of these gels by changes in their metal:ligand ratio. Further, we use the highly sensitive Eu(III) luminescence to obtain information about the chemical structure of the materials. In special, we take advantage of computational calculations to employ an indirect method for structural elucidation, in which the simulated luminescent properties of candidate structures are matched to the experimental data. With this strategy, we can propose molecular structures for different EuIDA gels. We also explore the usage of these gels for the loading of bioactive molecules such as OXA, observing that its aldose reductase activity remains present in the gel. We envision that the findings from this work could inspire the development of luminescent hydrogels with tunable rheology for applications such as 3D printing and imaging-guided drug delivery platforms. Finally, Eu(III) emission-based structural elucidation could be a powerful tool in the characterization of advanced materials.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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