Vertebral metastasis of hepatocellular carcinoma secondary to viral hepatitis B: case report of 2 patients.

Autor: Tchenadoyo Bayala YL; RHEUMATOLOGY DEPARTMENT, UNIVERSITY TEACHING HOSPITAL OF BOGODOGO, OUAGADOUGOU, BURKINA FASO., Tinni IA; RHEUMATOLOGY DEPARTMENT, UNIVERSITY TEACHING HOSPITAL OF BOGODOGO, OUAGADOUGOU, BURKINA FASO., Kabore F; RHEUMATOLOGY DEPARTMENT, UNIVERSITY TEACHING HOSPITAL OF BOGODOGO, OUAGADOUGOU, BURKINA FASO., Zabsonre/Tiendrebeogo JWS; RHEUMATOLOGY DEPARTMENT, UNIVERSITY TEACHING HOSPITAL OF BOGODOGO, OUAGADOUGOU, BURKINA FASO., Ouedraogo DD; RHEUMATOLOGY DEPARTMENT, UNIVERSITY TEACHING HOSPITAL OF BOGODOGO, OUAGADOUGOU, BURKINA FASO.
Jazyk: angličtina
Zdroj: Wiadomosci lekarskie (Warsaw, Poland : 1960) [Wiad Lek] 2024; Vol. 77 (2), pp. 358-362.
DOI: 10.36740/WLek202402126
Abstrakt: Bone metastases from liver cancer are rare. We report two cases of bone metastases revealing HBV-induced HCC. A 26-year-old african man presented with 4 months of low back pain in the context of general deterioration. Examination revealed a lumbar spinal syndrome and hepatomegaly. Abdominal ultrasound revealed a multinodular liver, and a CT scan of the spine revealed osteolytic lesions. Biological tests revealed a hepatic cytolysis syndrome, hepatic cholestasis and hepatocellular insufficiency. Alpha foetoprotein levels were elevated and hepatitis B serology was positive. We adopted the diagnosis of HCC of viral B origin with bone metastasis. The second case involved a 44-year-old African man admitted for 10 days with back pain. Examination revealed a spinal syndrome, paraplegia and hepatomegaly. A thoracic-abdominal-pelvic CT scan revealed typical HCC lesions and osteolytic lesions on the ribs, pelvis and vertebrae. The biology revealed a biological inflammatory syndrome, hepatic cytolysis, a hepatocellular insufficiency syndrome and a cholestasis syndrome. Alfa-feto proteins were elevated and HBV serology was positive. The diagnosis of bone metastasis of HCC secondary to HBV infection was accepted.
Databáze: MEDLINE