| Autor: |
Dhupar R; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Surgical and Research Services, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA., Powers AA; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Eisenberg SH; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Gemmill RM; Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA., Bardawil CE; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Udoh HM; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Cubitt A; aTyr Pharma, San Diego, CA 92121, USA., Nangle LA; aTyr Pharma, San Diego, CA 92121, USA., Soloff AC; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Surgical and Research Services, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA. |
| Abstrakt: |
Immunity has evolved to balance the destructive nature of inflammation with wound healing to overcome trauma, infection, environmental insults, and rogue malignant cells. The inflammatory response is marked by overlapping phases of initiation, resolution, and post-resolution remodeling. However, the disruption of these events can lead to prolonged tissue damage and organ dysfunction, resulting long-term disease states. Macrophages are the archetypic phagocytes present within all tissues and are important contributors to these processes. Pleiotropic and highly plastic in their responses, macrophages support tissue homeostasis, repair, and regeneration, all while balancing immunologic self-tolerance with the clearance of noxious stimuli, pathogens, and malignant threats. Neuropilin-2 (Nrp2), a promiscuous co-receptor for growth factors, semaphorins, and integrins, has increasingly been recognized for its unique role in tissue homeostasis and immune regulation. Notably, recent studies have begun to elucidate the role of Nrp2 in both non-hematopoietic cells and macrophages with cardiothoracic disease. Herein, we describe the unique role of Nrp2 in diseases of the heart and lung, with an emphasis on Nrp2 in macrophages, and explore the potential to target Nrp2 as a therapeutic intervention. |
