Analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory biomarkers in chronic kidney disease: impact of parathyroidectomy.

Autor:	Teng AK; Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil., Duque EJ; Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil., Crispilho SF; Universidade Nove de Julho, São Paulo, SP, Brazil., Domingues W; Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil., Jorgetti V; Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil., Reis LMD; Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil., Elias RM; Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil., Moysés RMA; Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil.
Jazyk:	English; Portuguese
Zdroj:	Jornal brasileiro de nefrologia [J Bras Nefrol] 2024 Apr 08; Vol. 46 (3), pp. e20230175. Date of Electronic Publication: 2024 Apr 08 (Print Publication: 2024).
DOI:	10.1590/2175-8239-JBN-2023-0175en
Abstrakt:	Introduction: Secondary hyperparathyroidism (SHPT) is one of the causes for inflammation in CKD. We assessed the impact of parathyroidectomy (PTX) on neutrophil-to-lymphocyte (N/L) and platelet-to-lymphocyte (P/L) ratios in SHPT patients. Methods: A total of 118 patients [hemodialysis (HD, n = 81), and transplant recipients (TX, n = 37)] undergoing PTX between 2015 and 2021 were analyzed. Results: There was a significant reduction in calcium and PTH levels in both groups, in addition to an increase in vitamin D. In the HD group, PTX did not alter N/L and P/L ratios. In the TX group, there was a reduction in N/L and P/L ratios followed by a significant increase in total lymphocyte count. Conclusion: N/L and P/L ratios are not reliable biomarkers of inflammation in SHPT patients undergoing PTX. Uremia, which induces a state of chronic inflammation in dialysis patients, and the use of immunosuppression in kidney transplant recipients are some of the confounding factors that prevent the use of this tool in clinical practice.
Databáze:	MEDLINE
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