Comparative study of the chemical composition, antioxidant, and antimicrobial activity of the essential oils extracted from Lavandula abrialis and Lavandula stoechas : in vitro and in silico analysis.

Autor: Radi M; Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Research Team of Chemistry of Bioactive Molecules and the Environment, Moulay Ismaïl University, Meknes, Morocco., Eddardar Z; Equipe Ecosystèmes et Sciences de l'environnement, Faculté des Sciences Appliquées, Ait Melloul-Université Ibn Zohr, Agadir, Morocco., Drioiche A; Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Research Team of Chemistry of Bioactive Molecules and the Environment, Moulay Ismaïl University, Meknes, Morocco., Remok F; Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Research Team of Chemistry of Bioactive Molecules and the Environment, Moulay Ismaïl University, Meknes, Morocco., Hosen ME; Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, Bangladesh., Zibouh K; Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Research Team of Chemistry of Bioactive Molecules and the Environment, Moulay Ismaïl University, Meknes, Morocco., Ed-Damsyry B; Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Research Team of Chemistry of Bioactive Molecules and the Environment, Moulay Ismaïl University, Meknes, Morocco., Bouatkiout A; Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Research Team of Chemistry of Bioactive Molecules and the Environment, Moulay Ismaïl University, Meknes, Morocco.; Laboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco., Amine S; Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Research Team of Chemistry of Bioactive Molecules and the Environment, Moulay Ismaïl University, Meknes, Morocco., Touijer H; Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Research Team of Chemistry of Bioactive Molecules and the Environment, Moulay Ismaïl University, Meknes, Morocco., Salamatullah AM; Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi Arabia., Bourhia M; Laboratory of Biotechnology and Natural Resources Valorization, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco., Ibenmoussa S; Laboratory of Therapeutic and Organic Chemistry, Faculty of Pharmacy, University of Montpellier, Montpellier, France., Zair T; Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Research Team of Chemistry of Bioactive Molecules and the Environment, Moulay Ismaïl University, Meknes, Morocco.
Jazyk: angličtina
Zdroj: Frontiers in chemistry [Front Chem] 2024 Mar 25; Vol. 12, pp. 1353385. Date of Electronic Publication: 2024 Mar 25 (Print Publication: 2024).
DOI: 10.3389/fchem.2024.1353385
Abstrakt: This work aims to add value to the Lavandula genus by identifying the chemical composition, antioxidant, and antimicrobial activities of two species lavender from Oulmès in Morocco; Lavandula abrialis and Lavandula stoechas . The uniqueness lies in the integrated approach that combines in vitro and in silico analyses to assess the biological properties of the essential oils (EO). The objective of this study is to enhance the significance of the Lavandula genus by analyzing the chemical composition, antioxidant properties, and antimicrobial effects of two lavender species found in Oulmès, Morocco: Lavandula abrialis and Lavandula stoechas. The distinctiveness is in the comprehensive methodology that merges in vitro and in silico investigations to evaluate the biological characteristics of the essential oils (EO). The extraction of essential oils (EO) by hydrodistillation from the aerial parts of Lavandula abrialis gave a high yield of essential oils (2.9%) compared to Lavandula stoechas (2.3%). A GC-MS analysis of the chemical composition revealed 56 chemical compounds, with some variation in the predominant components, representing between 99.98% and 100% of the EOs of the studied lavenders. Their antioxidant activity was assessed using the DPPH test. This method revealed that L. stoechas EO has a higher percentage of free radical inhibition than L. abrialis. The IC 50 values demonstrate that the antioxidant activity of ascorbic acid is higher (1.62 g/mL) than the EOs of tested plants. Noteworthy, the EO of L. stoechas is more potent (12.94 g/mL) than that of Lavandula tibialis (34.71 g/mL). Regrading, the antibacterial tests, the EO of L. abrialis was particularly active against Staphylococcus aureus BLACT, which is inhibited at a concentration of 6.25 g/mL, while L. stoechas EO has a strong effect on Escherichia coli , with a MIC of 1.56 g/mL. Concerning the antifungal activity of the EOs, yeasts showed sensitivity toward EOs extracted from both L. tibialis and L. stoechas . Moreover, an in silico study was conducted targeting sarA protein of S. aureus (PDB ID: 2fnp) and NADPH oxidase from Lavandula sanfranciscensis (PDB: 2CDU) and results showed that Ishwarone and Selina-3,7 (11)-diene exhibited highest binding energy with -9.8 and -10.8 kcal/mol respectively. Therefore, these two compounds could be used as an antibacterial and antioxidant agents however more experimental and molecular study should be required.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Radi, Eddardar, Drioiche, Remok, Hosen, Zibouh, Ed-Damsyry, Bouatkiout, Amine, Touijer, Salamatullah, Bourhia, Ibenmoussa and Zair.)
Databáze: MEDLINE
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