Paediatric Laryngeal Synovial Sarcoma: Dilemmas and Decision-Making.

Autor: Shein G; Department of Otolaryngology, Sydney Children's Hospital, Randwick, Sydney, NSW 2031, Australia., Potter AJ; Melanoma Institute Australia, Sydney, Australia.; Faculty of Medicine, University of Sydney, Sydney, Australia.; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.; Faculty of Medicine, University of New South Wales, Sydney, Australia., Loo C; Department of Anatomical Pathology, Prince of Wales Hospital, Randwick, Sydney, NSW 2031, Australia., Smee R; Department of Radiation Oncology, Sydney Children's Hospital, Randwick, Sydney, NSW 2031, Australia.; The UNSW Clinical Teaching School, Prince of Wales Hospital, Sydney, New South Wales, Australia.; Department of Radiation Oncology, Tamworth Base Hospital, Tamworth, New South Wales, Australia., Jacobson I; Department of Otolaryngology, Sydney Children's Hospital, Randwick, Sydney, NSW 2031, Australia.; Department of Otolaryngology, Prince of Wales Hospital, Randwick, Sydney, NSW 2031, Australia., Anazodo A; Kids Cancer Centre, Sydney Children's Hospital, Sydney, NSW 2031, Australia.; Nelune Cancer Centre, Prince of Wales Hospital, Sydney, NSW 2031, Australia.; School of Women's and Children's Health, University of New South Wales, Sydney, NSW 2031, Australia.
Jazyk: angličtina
Zdroj: Case reports in otolaryngology [Case Rep Otolaryngol] 2024 Apr 01; Vol. 2024, pp. 7574240. Date of Electronic Publication: 2024 Apr 01 (Print Publication: 2024).
DOI: 10.1155/2024/7574240
Abstrakt: Primary laryngeal synovial sarcoma is a rare head and neck cancer. We describe a case of synovial sarcoma of the larynx in a previously well 9-year-old boy with a one-month history of a progressively enlarging neck lump. He was referred to our institution after incomplete surgical excision of the then undifferentiated neck mass. A partial laryngectomy including wide local excision of the residual mass was performed. An ipsilateral level I-III neck dissection was also performed concurrently. Clear re-excision margins were achieved. The neck nodes were all negative for metastatic disease. Adjuvant local radiotherapy treatment was administered to reduce the probability of local recurrence. Four years following treatment completion, the patient remains in remission with no signs of treatment-related morbidity. A review of the published literature on laryngeal synovial sarcoma was undertaken. This case represents the youngest patient to be diagnosed with the condition. Surgical excision represents the mainstay of treatment of laryngeal synovial sarcoma. At more common sites of disease, adjuvant radiotherapy has been associated with lower rates of recurrence. However, there is the potential for significant morbidity from irradiating the neck of a paediatric patient. This case report explores the challenges in treating young patients with aggressive head and neck cancers when faced with little available evidence to guide decision-making.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2024 Gregory Shein et al.)
Databáze: MEDLINE
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