Four Undescribed Stilbenoid Derivatives from the Aerial Parts of Dendrobium officinale with their α-Glucosidase and α-Amylase Inhibitory Activity.

Autor: Hai Yen P; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Thuy Hang DT; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Huu Tai B; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Thi Cuc N; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Thanh Huong PT; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Thi Dung D; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Thi Trang D; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Van Hung N; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Van Hieu T; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Van Cuong P; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Dinh Hoang V; School of Chemistry and Life Sciences, Hanoi University of Science and Technology, 10000, Hanoi, Vietnam., Van Kiem P; Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Jul; Vol. 21 (7), pp. e202400708. Date of Electronic Publication: 2024 May 06.
DOI: 10.1002/cbdv.202400708
Abstrakt: In this study, four undescribed bibenzyl derivatives (1-4), together with seven known compounds (5-11) were isolated from the aerial parts of Dendrobium officinale. Their chemical structures were determined to be (7'S,8'S) -9''-acetyldendrocandin U (1), (7'S,8'S) -4'-methoxydendrocandin T (2), (7'R,8'S) -dendrocandin B (3), (1S,2R) -5'''-methoxydendrofindlaphenol C (4) by analyzing of the spectroscopic data including HR-ESI-MS, 1D-, and 2D-NMR spectra. The absolute configurations of compounds 1-4 were determined by the electronic circular dichroism (ECD) spectra. Compounds 1-3, 5, 10 and 11 inhibited α-glucosidase with the IC 50 values ranging from 56.3 to 165.3 μM, compounds 1-3, 5, 7-10 inhibited α-amylase with the IC 50 values ranging from 65.2 to 177.6 μM.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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