Dietary inflammatory index in relation to the progression of hepatic steatosis and liver fibrosis: evaluation by elastography/Fibroscan.

Autor: Miryan M; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran., Rashid SA; Department of surgery, college of medicine, Hawler Medical University, Kurdistan region, Erbil, Iraq., Navashenaq JG; Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran., Soleimani D; Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Research Center of Oils and Fats, Kermanshah University of Medical Sciences, Kermanshah, Iran., Nematy M; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Moludi J; Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. jmoludi@yahoo.com.; Research Center of Oils and Fats, Kermanshah University of Medical Sciences, Kermanshah, Iran. jmoludi@yahoo.com.
Jazyk: angličtina
Zdroj: BMC gastroenterology [BMC Gastroenterol] 2024 Apr 08; Vol. 24 (1), pp. 128. Date of Electronic Publication: 2024 Apr 08.
DOI: 10.1186/s12876-024-03209-8
Abstrakt: One of the proposed mechanisms by which nutrition influences the progression of hepatic steatosis to fibrosis is inflammation. The study investigated how the inflammatory potential of the diet affects the risk of liver damage in patients with nonalcoholic fatty liver disease (NAFLD), a condition where fat accumulates in the liver. This cross-sectional study included 170 outpatients with newly diagnosed NAFLD. This study used a device called Fibroscan® to measure the degree of liver fibrosis, which is the scarring of the liver tissue due to chronic inflammation. The study also used a tool called the Dietary Inflammatory Index (DII) to measure the inflammatory potential of the diet based on the intake of different foods and nutrients. In the findings of the study, patients with more severe fat accumulation in the liver (hepatic steatosis) had higher DII scores, meaning they had more inflammatory diets. The study also found that higher DII scores were associated with higher weight and body mass index (BMI). One standard deviation (SD) increase in DII scores was associated with a 0.29 kilopascal (95% CI: 0.10-0.44; P-value 0.001) increase in the mean liver stiffness, an indicator of liver fibrosis. The study concluded that patients with higher DII scores had a higher risk of developing liver fibrosis than those with lower DII scores, even after adjusting for confounding factors (odds ratio: 5.89; P-value: 0.001). The study suggested that eating less inflammatory foods may help prevent or slow down the progression of hepatic steatosis and liver in patients with NAFLD.
(© 2024. The Author(s).)
Databáze: MEDLINE
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