A large normative connectome for exploring the tractographic correlates of focal brain interventions.

Autor: Elias GJB; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, Canada.; Krembil Research Institute, University of Toronto, Toronto, Canada., Germann J; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, Canada.; Krembil Research Institute, University of Toronto, Toronto, Canada.; Center for Advancing Neurotechnological Innovation to Application (CRANIA), University Health Network, Toronto, Canada., Joel SE; GE Global Research, Bangalore, India., Li N; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Horn A; Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Einstein Center for Neurosciences Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, USA.; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA., Boutet A; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, Canada.; Krembil Research Institute, University of Toronto, Toronto, Canada.; Joint Department of Medical Imaging, University of Toronto, Toronto, Canada., Lozano AM; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, Canada. lozano@uhnresearch.ca.; Krembil Research Institute, University of Toronto, Toronto, Canada. lozano@uhnresearch.ca.
Jazyk: angličtina
Zdroj: Scientific data [Sci Data] 2024 Apr 08; Vol. 11 (1), pp. 353. Date of Electronic Publication: 2024 Apr 08.
DOI: 10.1038/s41597-024-03197-0
Abstrakt: Diffusion-weighted MRI (dMRI) is a widely used neuroimaging modality that permits the in vivo exploration of white matter connections in the human brain. Normative structural connectomics - the application of large-scale, group-derived dMRI datasets to out-of-sample cohorts - have increasingly been leveraged to study the network correlates of focal brain interventions, insults, and other regions-of-interest (ROIs). Here, we provide a normative, whole-brain connectome in MNI space that enables researchers to interrogate fiber streamlines that are likely perturbed by given ROIs, even in the absence of subject-specific dMRI data. Assembled from multi-shell dMRI data of 985 healthy Human Connectome Project subjects using generalized Q-sampling imaging and multispectral normalization techniques, this connectome comprises ~12 million unique streamlines, the largest to date. It has already been utilized in at least 18 peer-reviewed publications, most frequently in the context of neuromodulatory interventions like deep brain stimulation and focused ultrasound. Now publicly available, this connectome will constitute a useful tool for understanding the wider impact of focal brain perturbations on white matter architecture going forward.
(© 2024. The Author(s).)
Databáze: MEDLINE
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