Does compulsion explain addiction?

Autor: Heinz A; Department of Psychiatry and Neuroscience|CCM, NeuroCure Clinical Research Center, Berlin Institute of Health CCM, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Mental Health (DZPG), Berlin-Potsdam., Gutwinski S; Department of Psychiatry and Neuroscience|CCM, NeuroCure Clinical Research Center, Berlin Institute of Health CCM, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Bahr NS; Department of Psychiatry and Neuroscience|CCM, NeuroCure Clinical Research Center, Berlin Institute of Health CCM, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Mental Health (DZPG), Berlin-Potsdam., Spanagel R; Institute for Psychopharmacology, Medical Faculty Mannheim, Central Institute of Mental Health (CIMH), Heidelberg University, Mannheim, Germany., Di Chiara G; Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Cagliari, Italy.; Neuroscience Institute, National Research Council of Italy (CNR), Cagliari, Italy.
Jazyk: angličtina
Zdroj: Addiction biology [Addict Biol] 2024 Apr; Vol. 29 (4), pp. e13379.
DOI: 10.1111/adb.13379
Abstrakt: One of the leading drug addiction theories states that habits and the underlying neural process of a ventral to dorsal striatal shift are the building blocks of compulsive drug-seeking behaviour and that compulsion is the maladaptive persistence of responding despite adverse consequences. Here we discuss that compulsive behaviour as defined primarily from the perspective of animal experimentation falls short of the clinical phenomena and their neurobiological correlates. Thus for the human condition, the concept of compulsive habbits should be critically addressed and potentially revised.
(© 2024 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.)
Databáze: MEDLINE
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