Expression of netrin-1 in uterine serous carcinoma and its association with prognosis.

Autor: Ucuncu Kefeli A; Faculty of Medicine, Department of Radiation Oncology, Kocaeli University, Kocaeli, Turkey., Yaprak Bayrak B; Faculty of Medicine, Department of Pathology, Kocaeli University, Kocaeli, Turkey., Betul Tunce E; Faculty of Medicine, Department of Pathology, Kocaeli University, Kocaeli, Turkey., Vural C; Faculty of Medicine, Department of Pathology, Kocaeli University, Kocaeli, Turkey., Suyusal IH; Faculty of Medicine, Department of Radiation Oncology, Kocaeli University, Kocaeli, Turkey., Kefeli U; Division of Medical Oncology, Faculty of Medicine, Department of Internal Medicine, Kocaeli University, Kocaeli, Turkey., Aksu MG; Faculty of Medicine, Department of Radiation Oncology, Kocaeli University, Kocaeli, Turkey.
Jazyk: angličtina
Zdroj: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2024 Sep; Vol. 166 (3), pp. 1337-1344. Date of Electronic Publication: 2024 Apr 08.
DOI: 10.1002/ijgo.15513
Abstrakt: Background/objectives: At present, there are few biomarkers used to predict the prognosis of uterine serous carcinoma (USC). Netrin-1 may be a promising biomarker candidate. We investigated netrin-1 expression in USC tissues and healthy endometrial tissues to determine its relevance to disease prognosis.
Materials and Methods: Netrin-1 expression was examined in the tissues of 48 patients with USC and 30 patients with healthy benign endometrial tissues via immunohistochemistry.
Results: None of the healthy tissues were stained with netrin-1. In tumor tissues, the overall positivity rate of netrin-1 was 75%, detected as high expression in 17 patients (35%) and low in 19 (40%). Patients who had tumors with no netrin-1 expression (n = 12) had a median overall survival (OS) of 60.0 months (95% confidence interval [CI], 47-98), whereas patients who had tumors with low to strong netrin-1 expression (n = 33) had a lower median OS of 50 months, but the difference was not statistically significant (95% CI, 58-108; P = 0.531). Disease-free survival (DFS) was not statistically significant between the groups (95% CI, 67.7-115.9; P = 0.566). Patients with a tumor diameter ≥2 cm had higher netrin-1 expression than those with a tumor diameter of 2 cm (P = 0.027). We did not find any difference in overall and DFS when age, tumor stage, histology, tumor diameter, p53 status, lymphovascular space invasion, myometrial invasion, and lymph node metastasis were compared according to netrin-1 expression (P > 0.05).
Conclusion: Netrin-1 was expressed in USC but not in healthy tissues. Its expression was not associated with OS or DFS.
(© 2024 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.)
Databáze: MEDLINE
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