A controversial question: Can morphometry and clinical history be enough to diagnose hippocampal dysplasia?

Autor: Arruda IL; Epilepsy Research and Treatment Unit, Department of Neurology and Neurosurgery, Federal University of São Paulo (Unifesp), São Paulo, Brazil.; Neuroscience Sector, Department of Neurology and Neurosurgery, Federal University of São Paulo (UNIFESP), São Paulo, Brazil., Arruda RF; Epilepsy Research and Treatment Unit, Department of Neurology and Neurosurgery, Federal University of São Paulo (Unifesp), São Paulo, Brazil.; Neuroscience Sector, Department of Neurology and Neurosurgery, Federal University of São Paulo (UNIFESP), São Paulo, Brazil., da Silveira RMB; Epilepsy Research and Treatment Unit, Department of Neurology and Neurosurgery, Federal University of São Paulo (Unifesp), São Paulo, Brazil., Duarte JTC; Epilepsy Research and Treatment Unit, Department of Neurology and Neurosurgery, Federal University of São Paulo (Unifesp), São Paulo, Brazil., Guaranha MSB; Epilepsy Research and Treatment Unit, Department of Neurology and Neurosurgery, Federal University of São Paulo (Unifesp), São Paulo, Brazil., Guilhoto LM; Epilepsy Research and Treatment Unit, Department of Neurology and Neurosurgery, Federal University of São Paulo (Unifesp), São Paulo, Brazil., Carrete Júnior H; Diagnostic Imaging Sector, Department of Diagnostic Imaging, Federal University of São Paulo (Unifesp), São Paulo, Brazil., Stavale JN; Department of Pathology, Federal University of São Paulo (Unifesp), São Paulo, Brazil., Centeno RS; Neurosurgery Sector, Department of Neurology and Neurosurgery, Federal University of São Paulo (Unifesp), São Paulo, Brazil., Yacubian EMT; Epilepsy Research and Treatment Unit, Department of Neurology and Neurosurgery, Federal University of São Paulo (Unifesp), São Paulo, Brazil., Peixoto-Santos JE; Neuroscience Sector, Department of Neurology and Neurosurgery, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Epileptic disorders : international epilepsy journal with videotape [Epileptic Disord] 2024 Jun; Vol. 26 (3), pp. 382-391. Date of Electronic Publication: 2024 Apr 08.
DOI: 10.1002/epd2.20222
Abstrakt: The presence of dysmorphic neurons with strong cytoplasmatic accumulation of heavy non-phosphorylated neurofilament is crucial for the diagnostics of focal cortical dysplasia type II (FCDII). While ILAE's classification describes neocortical dysplasias, some groups have reported patients with mesial t abnormal neurons in the hippocampus of mesial temporal lobe epilepsy. Here we report a patient with such abnormal neurons in the hippocampus and compared it with previous reports of hippocampal dysplasia. Finally, we discuss the need for diagnostic criteria of hippocampal dysplasia.
(© 2024 International League Against Epilepsy.)
Databáze: MEDLINE
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