Early auditory processing abnormalities alter individual learning trajectories and sensitivity to computerized cognitive training in schizophrenia.

Autor:	Molina JL; Department of Psychiatry, University of California, San Diego, CA, USA.; VA Desert Pacific Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA., Joshi YB; Department of Psychiatry, University of California, San Diego, CA, USA.; VA Desert Pacific Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA., Nungaray JA; Department of Psychiatry, University of California, San Diego, CA, USA., Sprock J; Department of Psychiatry, University of California, San Diego, CA, USA.; VA Desert Pacific Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA., Attarha M; Department of R&D, Posit Science Corporation, San Francisco, CA, USA., Biagianti B; Department of Psychology, University of Milano-Bicocca, Milan, Italy., Thomas ML; Department of Psychology, Colorado State University, Fort Collins, CO, USA., Swerdlow NR; Department of Psychiatry, University of California, San Diego, CA, USA., Light GA; Department of Psychiatry, University of California, San Diego, CA, USA.; VA Desert Pacific Mental Illness Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA.
Jazyk:	angličtina
Zdroj:	Psychological medicine [Psychol Med] 2024 Jul; Vol. 54 (10), pp. 2669-2676. Date of Electronic Publication: 2024 Apr 08.
DOI:	10.1017/S0033291724000783
Abstrakt:	Background: Auditory system plasticity is a promising target for neuromodulation, cognitive rehabilitation and therapeutic development in schizophrenia (SZ). Auditory-based targeted cognitive training (TCT) is a 'bottom up' intervention designed to enhance the speed and accuracy of auditory information processing, which has been shown to improve neurocognition in certain SZ patients. However, the dynamics of TCT learning as a function of training exercises and their impact on neurocognitive functioning and therapeutic outcomes are unknown. Methods: Forty subjects (SZ, n = 21; healthy subjects (HS), n = 19) underwent comprehensive clinical, cognitive, and auditory assessments, including measurements of auditory processing speed (APS) at baseline and after 1-h of TCT. SZ patients additionally completed 30-hours of TCT and repeated assessments ~10-12 weeks later. Results: SZ patients were deficient in APS at baseline ( d = 0.96, p < 0.005) relative to HS. After 1-h of TCT, analyses revealed significant main effects of diagnosis ( d = 1.75, p = 0.002) and time ( d = 1.04, p < 0.001), and a diagnosis × time interaction ( d = 0.85, p = 0.02) on APS. APS learning effects were robust after 1-h in SZ patients ( d = 1.47, p < 0.001) and persisted throughout the 30-h of training. Baseline APS was associated with verbal learning gains after 30-h of TCT ( r = 0.51, p = 0.02) in SZ. Conclusions: TCT learning metrics may have prognostic utility and aid in the prospective identification of individuals likely to benefit from TCT. Future experimental medicine studies may advance predictive algorithms that enhance TCT-related clinical, cognitive and functional outcomes.
Databáze:	MEDLINE
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