| Autor: |
Wei X; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Key Laboratory of Chinese Medicinal Resource Recycling Utilization of State Administration of Traditional Chinese Medicine, National and Local Collaborative Engineering Center of Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China., Ma Y; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Key Laboratory of Chinese Medicinal Resource Recycling Utilization of State Administration of Traditional Chinese Medicine, National and Local Collaborative Engineering Center of Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China., Xu M; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Key Laboratory of Chinese Medicinal Resource Recycling Utilization of State Administration of Traditional Chinese Medicine, National and Local Collaborative Engineering Center of Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China., Heng D; Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Helicobacter pylori Research Centre, Nanjing Medical University, Nanjing, PR China., Onakpa MM; Department of Veterinary Pharmacology and Toxicology, University of Abuja, Abuja, Nigeria., Duan JA; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Key Laboratory of Chinese Medicinal Resource Recycling Utilization of State Administration of Traditional Chinese Medicine, National and Local Collaborative Engineering Center of Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China., Che CT; Department of Pharmaceutical Sciences, College of Pharmacy, the University of IL at Chicago, Chicago, IL, USA., Bi H; Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Helicobacter pylori Research Centre, Nanjing Medical University, Nanjing, PR China., Zhou J; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Key Laboratory of Chinese Medicinal Resource Recycling Utilization of State Administration of Traditional Chinese Medicine, National and Local Collaborative Engineering Center of Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China., Zhao M; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Key Laboratory of Chinese Medicinal Resource Recycling Utilization of State Administration of Traditional Chinese Medicine, National and Local Collaborative Engineering Center of Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China.; Department of Pharmaceutical Sciences, College of Pharmacy, the University of IL at Chicago, Chicago, IL, USA. |
| Abstrakt: |
A phytochemical investigation of the aerial parts of Mitracarpus hirtus afforded thirteen compounds, including a new naphthoquinone di-glycoside ( 1 ), three isopentenyl isoflavones ( 2 - 4 ), four flavonoids ( 5 - 8 ), three iridoid glycosides ( 9 - 11 ) and two coumarins ( 12 and 13 ). Their structures were elucidated based on extensive spectroscopic analyses, chemical methods, and the comparison with the literature. Among them, compound 1 possesses a 2-(3-methylnaphthalen-2-yl)acetic acid core with two glucosyl groups, compounds 2 - 4 are the first three representatives from the Rubiaceae family, and compounds 9 - 11 and 13 were isolated from Mitracarpus genus for the first time. Additionally, compounds 2 - 4 displayed potent antibacterial activities against Helicobacter pylori G27/HP159/JRES00015 (MIC = 4-16 μg/mL) , comparable to metronidazole. To date, wighteone ( 2 ) is the most active isoflavone with favourable predicted ADMET properties reported against H. pylori . |
