New Vibrio cholerae sequences from Eastern and Southern Africa alter our understanding of regional cholera transmission.

Autor: Xiao S; Division of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Abade A; Ministry of Health, Dar es Salaam, Tanzania.; Field Epidemiology and Laboratory Training Program, Nairobi, Kenya., Boru W; Field Epidemiology and Laboratory Training Program, Nairobi, Kenya., Kasambara W; Ministry of Health, Lilongwe, Malawi., Mwaba J; Center for Infectious Disease Research, Zambia.; Department of Pathology and Microbiology, University Teaching Hospital, Lusaka, Zambia., Ongole F; Ministry of Health, Kampala, Uganda., Mmanywa M; Ministry of Health, Dar es Salaam, Tanzania., Trovão NS; Fogarty International Center, National Institute of Health, Bethesda, MD, USA., Chilengi R; Zambia National Public Health Institute, Lusaka, Zambia., Kwenda G; Zambia National Public Health Institute, Lusaka, Zambia., Orach CG; Ministry of Health, Kampala, Uganda.; Makerere University School of Public Health, Kampala, Uganda., Chibwe I; Ministry of Health, Lilongwe, Malawi., Bwire G; Ministry of Health, Kampala, Uganda., Stine OC; University of Maryland School of Medicine, Baltimore, USA., Milstone AM; Division of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Lessler J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Azman AS; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Division of Tropical and Humanitarian Medicine, Geneva University Hospitals, Geneva, Switzerland.; Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals, Geneva, Switzerland., Luo W; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Murt K; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, Zambia., Sack DA; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Debes AK; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Wohl S; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Jazyk: angličtina
Zdroj: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Mar 30. Date of Electronic Publication: 2024 Mar 30.
DOI: 10.1101/2024.03.28.24302717
Abstrakt: Despite ongoing containment and vaccination efforts, cholera remains prevalent in many countries in sub-Saharan Africa. Part of the difficulty in containing cholera comes from our lack of understanding of how it circulates throughout the region. To better characterize regional transmission, we generated and analyzed 118 Vibrio cholerae genomes collected between 2007-2019 from five different countries in Southern and Eastern Africa. We showed that V. cholerae sequencing can be successful from a variety of sample types and filled in spatial and temporal gaps in our understanding of circulating lineages, including providing some of the first sequences from the 2018-2019 outbreaks in Uganda, Kenya, Tanzania, Zambia, and Malawi. Our results present a complex picture of cholera transmission in the region, with multiple lineages found to be co-circulating within several countries. We also find evidence that previously identified sporadic cases may be from larger, undersampled outbreaks, highlighting the need for careful examination of sampling biases and underscoring the need for continued and expanded cholera surveillance across the African continent.
Databáze: MEDLINE