Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis.

Autor:	Mattke J; Baylor University, Institute of Biomedical Studies, Waco, TX, United States., Darden CM; Baylor University Medical Center, Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX, United States., Lawrence MC; Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, United States., Kuncha J; Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, United States., Shah YA; Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, United States., Kane RR; Baylor University, Institute of Biomedical Studies, Waco, TX, United States., Naziruddin B; Baylor University Medical Center, Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Mar 22; Vol. 15, pp. 1362727. Date of Electronic Publication: 2024 Mar 22 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1362727
Abstrakt:	Acute pancreatitis is a complex inflammatory disease resulting in extreme pain and can result in significant morbidity and mortality. It can be caused by several factors ranging from genetics, alcohol use, gall stones, and ductal obstruction caused by calcification or neutrophil extracellular traps. Acute pancreatitis is also characterized by immune cell infiltration of neutrophils and M1 macrophages. Toll-like receptor 4 (TLR4) is a pattern recognition receptor that has been noted to respond to endogenous ligands such as high mobility group box 1 (HMGB1) protein and or exogenous ligands such as lipopolysaccharide both of which can be present during the progression of acute pancreatitis. This receptor can be found on a variety of cell types from endothelial cells to resident and infiltrating immune cells leading to production of pro-inflammatory cytokines as well as immune cell activation and maturation resulting in the furthering of pancreatic damage during acute pancreatitis. In this review we will address the various mechanisms mediated by TLR4 in the advancement of acute pancreatitis and how targeting this receptor could lead to improved outcomes for patients suffering from this condition. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Mattke, Darden, Lawrence, Kuncha, Shah, Kane and Naziruddin.)
Databáze:	MEDLINE
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