Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood.

Autor:	Jameson AN; Neuroscience Graduate Program, Vanderbilt University, Nashville, TN, 37232, USA., Siemann JK; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA.; Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN, 37232, USA., Grueter CA; Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN, 37232, USA.; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, 37232, USA.; Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA., Grueter B; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA., McMahon DG; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37232, USA.; Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.; Department of Biological Sciences, Vanderbilt University, Nashville, TN, 37232, USA.
Jazyk:	angličtina
Zdroj:	Neurobiology of sleep and circadian rhythms [Neurobiol Sleep Circadian Rhythms] 2024 Mar 26; Vol. 16, pp. 100103. Date of Electronic Publication: 2024 Mar 26 (Print Publication: 2024).
DOI:	10.1016/j.nbscr.2024.100103
Abstrakt:	Day length, or photoperiod, is a reliable environmental cue encoded by the brain's circadian clock that indicates changing seasons and induces seasonal biological processes. In humans, photoperiod, age, and sex have been linked to seasonality in neuropsychiatric disorders, as seen in Seasonal Affective Disorder, Major Depressive Disorder, and Bipolar Disorder. The nucleus accumbens is a key locus for the regulation of motivated behaviors and neuropsychiatric disorders. Using periadolescent and young adult male and female mice, here we assessed photoperiod's effect on serotonin and dopamine tissue content in the nucleus accumbens core, as well as on accumbal synaptic dopamine release and uptake. We found greater serotonin and dopamine tissue content in the nucleus accumbens from young adult mice raised in a Short winter-like photoperiod. In addition, dopamine release and clearance were greater in the nucleus accumbens from young adult mice raised in a Long summer-like photoperiod. Importantly, we found that photoperiod's effects on accumbal dopamine tissue content and release were sex-specific to young adult females. These findings support that in mice there are interactions across age, sex, and photoperiod that impact critical monoamine neuromodulators in the nucleus accumbens which may provide mechanistic insight into the age and sex dependencies in seasonality of neuropsychiatric disorders in humans. Competing Interests: The authors declare no conflict of interest. (© 2024 The Authors.)
Databáze:	MEDLINE
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