Isolation and Antitumoral Effect of a New Siphonochilone Derivative from African Ginger.

Autor:	Fuentes-Ríos D; Dep. of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Málaga, Spain., Ortigosa A; Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.; Dep. of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18071 Granada, Spain.; Instituto de Investigación Biosanitaria ibs, Granada, 18012 Granada, Spain., Quiñonero F; Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.; Instituto de Investigación Biosanitaria ibs, Granada, 18012 Granada, Spain., Melguizo C; Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.; Dep. of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18071 Granada, Spain.; Instituto de Investigación Biosanitaria ibs, Granada, 18012 Granada, Spain., Ortiz R; Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.; Dep. of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18071 Granada, Spain.; Instituto de Investigación Biosanitaria ibs, Granada, 18012 Granada, Spain., Prados J; Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.; Dep. of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18071 Granada, Spain.; Instituto de Investigación Biosanitaria ibs, Granada, 18012 Granada, Spain., Díaz A; Dep. of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Málaga, Spain., López-Romero JM; Dep. of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Málaga, Spain.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2024 Mar 20; Vol. 9 (13), pp. 15718-15722. Date of Electronic Publication: 2024 Mar 20 (Print Publication: 2024).
DOI:	10.1021/acsomega.4c01914
Abstrakt:	A new eusdesmane sesquiterpenoid, characterized as 3,5,8a-trimethyl-8-oxo-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3- b ]furan-5-yl acetate ( 1 ), has been isolated from the rhizomes of the South African variety of wild ginger ( Siphonochilus aethiopicus (Schweinf) B. L. Burtt). The compound was obtained by silica gel column chromatography. Its structure was elucidated by nuclear magnetic resonance spectroscopy (NMR) and mass-spectrometric (MS) analyses, including 1D-, 2D-NMR, and HR-LCMS. We also investigated the cytotoxic effect of 1 on a panel of cancer cell lines, human breast, pancreas, lung, colon, and central nervous system cancer lines. The data are not encouraging since its antitumor effect is poor. Nonetheless, the discovery of new molecules may provide a source of new compounds with important biological effects applicable to the field of medicine. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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