Evaluation of serum pro/anti-angiogenic biomarkers in hyperglycemic rats treated with Securigera securidaca seeds, alone and in combination with Glibenclamide.
| Autor: | Bahreini E; Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran., Babaei M; Department of Clinical Sciences, Faculty of Veterinary Sciences, Bu-Ali Sina University, Hamedan, Iran., Mohammadi F; Department of Veterinary, Agriculture Faculty, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran., Alizadeh-Fanalou S; Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cardiovascular and thoracic research [J Cardiovasc Thorac Res] 2024; Vol. 16 (1), pp. 8-14. Date of Electronic Publication: 2024 Mar 13. |
| DOI: | 10.34172/jcvtr.32960 |
| Abstrakt: | Introduction: Herbal medicines are commonly used by many people with diabetes in addition to standard treatment. Plants contain numerous known and unknown compounds that may exacerbate or ameliorate diabetes complications. Therefore, it is crucial to be aware of the side effects of these herbs before prescribing them. This study aimed to investigate the effects of hydroalcoholic extracts of Securigera securidaca (HESS) seeds alone and in combination with glibenclamide on the angiogenic/anti-angiogenic balance in streptozotocin (STZ)-induced diabetic rats. Methods: Groups involved in this animal study included diabetic and healthy controls, three doses of HESS, glibenclamide, and combination therapy. Serum samples were collected and analyzed for a vascular endothelial growth factor (VEGF), fibroblast growth factor 21 (FGF21), fetal liver kinase 1 (FLK-1), soluble fms-like tyrosine kinase 1 (sFLT-1), and transforming growth factor -beta (TGF-β). Results: Induction of diabetes increased VEGF, FGF21, and TGF-β serum levels and decreased circulating FLK-1 and sFLT-1 factors. Herbal extract, except TGF-β, had little effect on the above blood levels even at the highest doses. Glibenclamide was more effective than the highest dose of HESS in improving the vascular complications of diabetes. Combination therapy with the highest dose of HESS partly enhanced the glibenclamide effects. Conclusion: Compared with glibenclamide as a standard chemical drug, HESS had no significant effects on the blood levels of the pro/anti-angiogenesis factor in diabetic rats. Glibenclamide attenuated the levels of the biomarkers and its effects were somewhat enhanced in combination with the highest dose of HESS. Competing Interests: There are no conflicts of interest to declare. (© 2024 The Author(s).) |
| Databáze: | MEDLINE |
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