DFT/TDDFT calculations of geometry optimization, electronic structure and spectral properties of clevudine and telbivudine for treatment of chronic hepatitis B.

Autor: Tegegn DF; Department of Chemistry, College of Natural and Computational Science, Dambi Dollo University, Dambi Dollo, P. O. Box. 260, Oromia, Ethiopia., Belachew HZ; Department of Chemistry, College of Natural and Computational Science, Dambi Dollo University, Dambi Dollo, P. O. Box. 260, Oromia, Ethiopia., Salau AO; Department of Electrical/Electronics and Computer Engineering, Afe Babalola University, Ado-Ekiti, Nigeria. ayodejisalau98@gmail.com.; Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India. ayodejisalau98@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Apr 08; Vol. 14 (1), pp. 8146. Date of Electronic Publication: 2024 Apr 08.
DOI: 10.1038/s41598-024-58599-2
Abstrakt: Chronic hepatitis B remains a worldwide health concern. Presently, many drugs, such as Clevudine and Telbivudine, are recommended for the treatment of chronic hepatitis B disease. For this purpose, the quantum chemical analysis of E LUMO-HOMO (E gap ), ionization potential (IP), electron affinity (EA), electronegativity (EN), chemical hardness (η), chemical potential (μ), chemical softness (S), electrophilicity index (ω), electron accepting capability (ω + ), electron-donating capability (ω - ), Nucleophilicity index (N), additional electronic charge (∆N max ), Optical softness (σ 0 ) and Dipole Moment, IR and UV-Vis spectra, molecular electrostatic potential (MEP) profile, Mulliken charge analysis, natural bond orbital (NBO) were examined in this study. The dipole moment of the compounds suggests their binding pose and predicted binding affinity. The electrophilic and nucleophilic regions were identified, and techniques such as NBO, UV-Vis, and IR were used to gain insights into the molecular structure, electronic transitions, and potential drug design for Hepatitis B treatment. Calculations for this study were carried out using the Gaussian 09 program package coupled with the DFT/TDDFT technique. The hybrid B3LYP functional method and the 6-311++G(d, p) basis set were used for the calculations.
(© 2024. The Author(s).)
Databáze: MEDLINE
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