The PLA 2 inhibitor from Crotalus durissus terrificus blood plasma (CNF) inhibits group III-PLA 2 from honeybee venom.

Autor: Ortolani PL; Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias (FUNED), Belo Horizonte, Minas Gerais, Brazil., Campos PC; Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias (FUNED), Belo Horizonte, Minas Gerais, Brazil., Fortes-Dias CL; Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias (FUNED), Belo Horizonte, Minas Gerais, Brazil. Electronic address: consuelo.latorre@funed.mg.gov.br.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 May 06; Vol. 242, pp. 107711. Date of Electronic Publication: 2024 Apr 05.
DOI: 10.1016/j.toxicon.2024.107711
Abstrakt: Crotalus neutralizing factor (CNF) is an endogenous glycoprotein from Crotalus durissus terrificus snake blood that inhibits secretory phospholipases A 2 (sPLA 2 ) from the Viperid but not from Elapid venoms (subgroups IA and IIA, respectively). In the present study, we demonstrated that CNF can inhibit group III-PLA 2 from bee venom by forming a stable enzyme-inhibitor complex. This finding opens up new possibilities for the potential use of CNF and/or CNF-based derivatives in the therapeutics of bee stings.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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