A novel, reverse-phase-shifting, thermoreversible foaming hydrogel containing antibiotics for the treatment of thermal burns in a swine model - A pilot study.

Autor: Donaldson RI; Critical Innovations LLC, 4228 Marine Avenue, Los Angeles, CA 90260, USA; Department of Emergency Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; Department of Emergency Medicine, Harbor-UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA; Department of Epidemiology, UCLA - Fielding School of Public Health, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA. Electronic address: rdonaldson@criticalinnovations.com., Armstrong JK; Critical Innovations LLC, 4228 Marine Avenue, Los Angeles, CA 90260, USA., Buchanan OJ; Critical Innovations LLC, 4228 Marine Avenue, Los Angeles, CA 90260, USA., Graham TL; Benchmark Biotech LLC, 1225 NE 2nd Ave, DCM 2nd Floor, Portland, OR 97232, USA., Cambridge JS; Critical Innovations LLC, 4228 Marine Avenue, Los Angeles, CA 90260, USA., Cristerna NN; Critical Innovations LLC, 4228 Marine Avenue, Los Angeles, CA 90260, USA., Goldenberg D; Critical Innovations LLC, 4228 Marine Avenue, Los Angeles, CA 90260, USA., Tanen CDA; Department of Emergency Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; Department of Emergency Medicine, Harbor-UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA., Fisher TC; Critical Innovations LLC, 4228 Marine Avenue, Los Angeles, CA 90260, USA., Tolles J; Department of Emergency Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; Department of Emergency Medicine, Harbor-UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA., Burns CJ; Brigham and Women's Hospital, Division of Trauma, Burn and Surgical Critical Care, 45 Francis Street, Boston, MA 02115, USA., Ross JD; Benchmark Biotech LLC, 1225 NE 2nd Ave, DCM 2nd Floor, Portland, OR 97232, USA.
Jazyk: angličtina
Zdroj: Burns : journal of the International Society for Burn Injuries [Burns] 2024 Aug; Vol. 50 (6), pp. 1578-1585. Date of Electronic Publication: 2024 Mar 15.
DOI: 10.1016/j.burns.2024.03.018
Abstrakt: Background: This study compared a novel topical hydrogel burn dressing (CI-PRJ012) to standard of care (silver sulfadiazine) and to untreated control in a swine thermal burn model, to assess for wound healing properties both in the presence and absence of concomitant bacterial inoculation.
Methods: Eight equal burn wounds were created on six Yorkshire swine. Half the wounds were randomized to post-burn bacterial inoculation. Wounds were subsequently randomized to three treatments groups: no intervention, CI-PRJ012, or silver sulfadiazine cream. At study end, a blinded pathologist evaluated wounds for necrosis and bacterial colonization.
Results: When comparing CI-PRJ012 and silver sulfadiazine cream to no treatment, both agents significantly reduced the amount of necrosis and bacteria at 7 days after wound creation (p < 0.01, independently for both). Further, CI-PRJ012 was found to be significantly better than silver sulfadiazine (p < 0.02) in reducing bacterial colonization. For wound necrosis, no significant difference was found between silver sulfadiazine cream and CI-PRJ012 (p = 0.33).
Conclusions: CI-PRJ012 decreases necrosis and bacterial colonization compared to no treatment in a swine model. CI-PRJ012 appeared to perform comparably to silver sulfadiazine. CI-PRJ012, which is easily removed with the application of room-temperature water, may provide clinical advantages over silver sulfadiazine.
Competing Interests: Declaration of Competing Interest TLG and JDR have no conflicts of interest to declare. CJB, JT, and DAT were paid consultants on this project. RID, TCF, OJB, JSC, DG, NNC, and JKA are employees of Critical Innovations. RID, TCF, OJB, JSC, NNC, and JKA are inventors of CI-PRJ012 technology, with related intellectual property rights.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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