Toothpaste containing TiF 4 and chitosan against erosive tooth wear in situ.

Autor: Francese MM; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil., Urasaki BAN; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil., de Barros MC; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil., Ferrari CR; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil., Grizzo LT; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil., Magalhães AC; Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil. Electronic address: acm@usp.br.
Jazyk: angličtina
Zdroj: Journal of dentistry [J Dent] 2024 Jun; Vol. 145, pp. 104977. Date of Electronic Publication: 2024 Apr 04.
DOI: 10.1016/j.jdent.2024.104977
Abstrakt: Objective: This study compared the protective effect of an experimental TiF 4 /Chitosan toothpaste with a commercial toothpaste on the prevention of erosive tooth wear (ETW) in situ.
Methods: Fifteen subjects took part in this crossover and double-blind study, in which they wore a palatal appliance containing 4 bovine enamel and 4 dentin in 3 phases (5 days each). Half of the samples were subjected to erosive challenges (90 s in 0.1 % citric acid, pH 2.5, 4 times/day), and the other half to erosive plus abrasive challenges (15 s plus 45 s of contact, 2 times/day). The phases corresponded to the application of the different toothpastes: 1) TiF 4 (1400 ppm F - ) plus Chitosan, 2) Elmex®, Erosion Protection (1400 ppm F - , Chitosan), and 3) Placebo (negative control). Tooth wear was measured using contact profilometry (μm) and submitted to two-way RM ANOVA/Tukey test (p < 0.05).
Results: No significant differences were detected between the experimental and commercial toothpastes, regardless of the challenge on both tissues. Both significantly reduce ETW compared to negative control (p < 0.0006). Tooth wear was increased by brushing only on eroded enamel (p < 0.01), but not on dentin (p = 0.6085). TiF 4 /Chitosan [erosion 2.98 ± 1.12 μm vs. erosion and abrasion 3.12 ± 1.33 μm] and Elmex® toothpastes [erosion 2.35 ± 0.93 μm vs. erosion and abrasion 2.98 ± 1.0 μm] minimized the impact of brushing compared to placebo on enamel [erosion 4.62 ± 1.48 μm vs. erosion and abrasion 5.15 ± 1.50 μm].
Conclusions: TiF 4 plus chitosan toothpastes showed to be effective in minimizing the ETW as the commercial toothpaste is in situ.
Clinical Relevance: The experimental toothpaste has similar effect against ETW compared to the commercial toothpaste. Considering the increased ETW prevalence worldwide, this result supports clinical trials and a possible application of this experimental anti-erosive toothpaste in the future.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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