Conversion map from quantitative parameter mapping to myelin water fraction: comparison with R 1 ·R 2 * and myelin water fraction in white matter.

Autor: Kitano S; Graduate of Health Science, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.; Clinical Radiology Service, Kyoto University Hospital, Kyoto, 606-8507, Japan., Kanazawa Y; Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan. yk@tokushima-u.ac.jp., Harada M; Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan., Taniguchi Y; FUJIFILM Healthcare Corporation, 2-1 Shintoyofuta, Kashiwa, Chiba, 277-0804, Japan., Hayashi H; College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa, 920-0942, Japan., Matsumoto Y; Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan., Ito K; FUJIFILM Healthcare Corporation, 2-1 Shintoyofuta, Kashiwa, Chiba, 277-0804, Japan., Bito Y; FUJIFILM Healthcare Corporation, 2-1 Shintoyofuta, Kashiwa, Chiba, 277-0804, Japan., Haga A; Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.
Jazyk: angličtina
Zdroj: Magma (New York, N.Y.) [MAGMA] 2024 Oct; Vol. 37 (5), pp. 887-898. Date of Electronic Publication: 2024 Apr 06.
DOI: 10.1007/s10334-024-01155-w
Abstrakt: Objective: To clarify the relationship between myelin water fraction (MWF) and R 1 ⋅R 2 * and to develop a method to calculate MWF directly from parameters derived from QPM, i.e., MWF converted from QPM (MWF QPM ).
Materials and Methods: Subjects were 12 healthy volunteers. On a 3 T MR scanner, dataset was acquired using spoiled gradient-echo sequence for QPM. MWF and R 1 ⋅R 2 * maps were derived from the multi-gradient-echo (mGRE) dataset. Volume-of-interest (VOI) analysis using the JHU-white matter (WM) atlas was performed. All the data in the 48 WM regions measured VOI were plotted, and quadratic polynomial approximations of each region were derived from the relationship between R 1 ·R 2 * and the two-pool model-MWF. The R 1 ·R 2 * map was converted to MWF QPM map. MWF atlas template was generated using converted to MWF from R 1 ·R 2 * per WM region.
Results: The mean MWF and R 1 ·R 2 * values for the 48 WM regions were 11.96 ± 6.63%, and 19.94 ± 4.59 s -2 , respectively. A non-linear relationship in 48 regions of the WM between MWF and R 1 ·R 2 * values was observed by quadratic polynomial approximation (R 2  ≥ 0.963, P < 0.0001).
Discussion: MWF QPM map improved image quality compared to the mGRE-MWF map. Myelin water atlas template derived from MWF QPM may be generated with combined multiple WM regions.
(© 2024. The Author(s), under exclusive licence to European Society for Magnetic Resonance in Medicine and Biology (ESMRMB).)
Databáze: MEDLINE
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