MMP1, IL-1β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors.

Autor: Nagasaka H; Department of Urology, Kanagawa Cancer Center, Yokohama, Kanagawa, 241-8515, Japan., Kishida T; Department of Urology, Kanagawa Cancer Center, Yokohama, Kanagawa, 241-8515, Japan. kishidat@kcch.jp., Kouro T; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, 241-8515, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center, Kanagawa, Japan., Igarashi Y; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, 241-8515, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center, Kanagawa, Japan., Takebe S; Department of Urology, Kanagawa Cancer Center, Yokohama, Kanagawa, 241-8515, Japan., Yamamoto S; Department of Urology, Kanagawa Cancer Center, Yokohama, Kanagawa, 241-8515, Japan., Kondo T; Department of Urology, Kanagawa Cancer Center, Yokohama, Kanagawa, 241-8515, Japan., Koizumi M; Department of Urology, Kanagawa Cancer Center, Yokohama, Kanagawa, 241-8515, Japan., Terao H; Department of Urology, Kanagawa Cancer Center, Yokohama, Kanagawa, 241-8515, Japan., Suzuki T; Department of Urology, Kanagawa Cancer Center, Yokohama, Kanagawa, 241-8515, Japan., Nakaigawa N; Department of Urology, Kanagawa Cancer Center, Yokohama, Kanagawa, 241-8515, Japan., Himuro H; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, 241-8515, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center, Kanagawa, Japan., Wei F; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, 241-8515, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center, Kanagawa, Japan., Sasada T; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, 241-8515, Japan. tsasada@kcch.jp.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center, Kanagawa, Japan. tsasada@kcch.jp.
Jazyk: angličtina
Zdroj: International journal of clinical oncology [Int J Clin Oncol] 2024 Jun; Vol. 29 (6), pp. 832-839. Date of Electronic Publication: 2024 Apr 06.
DOI: 10.1007/s10147-024-02477-4
Abstrakt: Background: Few studies have reported reliable prognostic factors for immune checkpoint inhibitors (ICIs) in renal cell carcinoma (RCC). Therefore, we investigated prognostic factors in patients treated with ICIs for unresectable or metastatic RCC.
Methods: We included 43 patients who received ICI treatment for RCC between January 2018 and October 2021. Blood samples were drawn before treatment, and 73 soluble factors in the plasma were analyzed using a bead-based multiplex assay. We examined factors associated with progression-free survival (PFS), overall survival (OS), and immune-related adverse events (irAE) using the Chi-squared test, Kaplan-Meier method, and the COX proportional hazards model.
Results: Patients exhibited a median PFS and OS of 212 and 783 days, respectively. Significant differences in both PFS and OS were observed for MMP1 (PFS, p < 0.001; OS, p = 0.003), IL-1β (PFS, p = 0.021; OS, p = 0.008), sTNFR-1 (PFS, p = 0.017; OS, p = 0.005), and IL-6 (PFS, p = 0.004; OS, p < 0.001). Multivariate analysis revealed significant differences in PFS for MMP1 (hazard ratio [HR] 5.305, 95% confidence interval [CI], 1.648-17.082; p = 0.005) and OS for IL-6 (HR 23.876, 95% CI, 3.426-166.386; p = 0.001). Moreover, 26 patients experienced irAE, leading to ICI discontinuation or withdrawal. MMP1 was significantly associated with irAE (p = 0.039).
Conclusion: MMP1 may be associated with severe irAE, and MMP1, IL-1β, sTNFR-1, and IL-6 could serve as prognostic factors in unresectable or metastatic RCC treated with ICIs. MMP1 and IL-6 were independent predictors of PFS and OS, respectively. Thus, inhibiting these soluble factors may be promising for enhancing antitumor responses in patients with RCC treated with ICIs.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: