Contamination of dairy products with tris(2,4-di-tert-butylphenyl) phosphite and implications for human exposure.

Autor: Zhou R; College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, China; Laboratory of Key Technologies of Major Comprehensive Guarantee of Food Safety for State Market Regulation, Beijing Institute of Food Inspection and Research (Beijing Municipal Center for Food Safety Monitoring and Risk Assessment), Beijing, 100094, China., Geng J; Laboratory of Key Technologies of Major Comprehensive Guarantee of Food Safety for State Market Regulation, Beijing Institute of Food Inspection and Research (Beijing Municipal Center for Food Safety Monitoring and Risk Assessment), Beijing, 100094, China., Jiang J; Laboratory of Key Technologies of Major Comprehensive Guarantee of Food Safety for State Market Regulation, Beijing Institute of Food Inspection and Research (Beijing Municipal Center for Food Safety Monitoring and Risk Assessment), Beijing, 100094, China., Shao B; College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, China; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China. Electronic address: shaobingch@sina.com., Lin L; Laboratory of Key Technologies of Major Comprehensive Guarantee of Food Safety for State Market Regulation, Beijing Institute of Food Inspection and Research (Beijing Municipal Center for Food Safety Monitoring and Risk Assessment), Beijing, 100094, China., Mu T; Laboratory of Key Technologies of Major Comprehensive Guarantee of Food Safety for State Market Regulation, Beijing Institute of Food Inspection and Research (Beijing Municipal Center for Food Safety Monitoring and Risk Assessment), Beijing, 100094, China., Wang B; College of Science, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, China., Liu T; Laboratory of Key Technologies of Major Comprehensive Guarantee of Food Safety for State Market Regulation, Beijing Institute of Food Inspection and Research (Beijing Municipal Center for Food Safety Monitoring and Risk Assessment), Beijing, 100094, China.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2024 Aug 01; Vol. 448, pp. 139144. Date of Electronic Publication: 2024 Mar 31.
DOI: 10.1016/j.foodchem.2024.139144
Abstrakt: Tris(2,4-di-tert-butylphenyl) phosphite (AO168), an organophosphite antioxidant, can be oxidized to tris(2,4-di-tert-butylphenyl) phosphate (AO168 = O) during the production, processing, and application of plastics. AO168 = O can be further transformed to bis(2,4-di-tert-butylphenyl) phosphate and 2,4-di-tert-butylphenol. Here, we discovered the contamination of AO168 and its transformation products in dairy products for the first time. More samples contained AO168 (mean concentration: 8.78 ng/g wet weight [ww]), bis(2,4-di-tert-butylphenyl) phosphate (mean:11.1 ng/g ww) and 2,4-di-tert-butylphenol (mean: 46.8 ng/g ww) than AO168 = O (mean: 40.2 ng/g ww). The concentrations of AO168 and its transformation products were significantly correlated, and differed with the packaging material and storage conditions of the product. Estimated daily intakes (EDIs) of AO168 and its transformation products were calculated. Although the overall dietary risks were below one, transformation products accounted for 96.7% of the total hazard quotients. The high-exposure EDIs of total AO168 were above the threshold of toxicological concern (300 ng/kg bw/day), and deserve continual monitoring.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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