Determination of copper status by five biomarkers in serum of healthy women.

Autor: Chillon TS; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin, Jena, Germany; Max Rubner Center for Cardiovascular Metabolic Renal Research (CMR), Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Hessische Straße 3-4, Berlin D-10115, Germany., Tuchtenhagen M; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin, Jena, Germany; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany., Schwarz M; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin, Jena, Germany; Department of Nutritional Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Jena 07743, Germany., Hackler J; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin, Jena, Germany; Max Rubner Center for Cardiovascular Metabolic Renal Research (CMR), Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Hessische Straße 3-4, Berlin D-10115, Germany., Heller R; Max Rubner Center for Cardiovascular Metabolic Renal Research (CMR), Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Hessische Straße 3-4, Berlin D-10115, Germany; Bundeswehr Hospital Berlin, Clinic of Traumatology and Orthopaedics, Berlin D-10115, Germany; Technische Universität Berlin, Department of Food Chemistry and Toxicology, Straße des 17. Juni 135, Berlin 10623, Germany., Kaghazian P; Orthopedic and Trauma Surgery, Frohsinnstraße 12, Aschaffenburg D-63739, Germany., Moghaddam A; Orthopedic and Trauma Surgery, Frohsinnstraße 12, Aschaffenburg D-63739, Germany., Schomburg L; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin, Jena, Germany; Max Rubner Center for Cardiovascular Metabolic Renal Research (CMR), Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Hessische Straße 3-4, Berlin D-10115, Germany., Haase H; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin, Jena, Germany; Technische Universität Berlin, Department of Food Chemistry and Toxicology, Straße des 17. Juni 135, Berlin 10623, Germany., Kipp AP; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin, Jena, Germany; Department of Nutritional Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Jena 07743, Germany., Schwerdtle T; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin, Jena, Germany; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Maares M; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin, Jena, Germany; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany; Technische Universität Berlin, Department of Food Chemistry and Toxicology, Straße des 17. Juni 135, Berlin 10623, Germany. Electronic address: maares@tu-berlin.de.
Jazyk: angličtina
Zdroj: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2024 Jul; Vol. 84, pp. 127441. Date of Electronic Publication: 2024 Mar 22.
DOI: 10.1016/j.jtemb.2024.127441
Abstrakt: Background: The essential trace element copper is relevant for many important physiological processes. Changes in copper homeostasis can result from disease and affect human health. A reliable assessment of copper status by suitable biomarkers may enable fast detection of subtle changes in copper metabolism. To this end, additional biomarkers besides serum copper and ceruloplasmin (CP) concentrations are required.
Objectives: The aim of this study was to investigate the emerging copper biomarkers CP oxidase (CPO) activity, exchangeable copper (CuEXC) and labile copper in serum of healthy women and compare them with the conventional biomarkers total serum copper and CP.
Method and Main Findings: This observational study determined CPO activity, the non CP-bound copper species CuEXC and labile copper, total serum copper and CP in sera of 110 healthy women. Samples were collected at four time points over a period of 24 weeks. The concentrations of total serum copper and CP were within the reference ranges. The comparison of all five biomarkers provided insight into their relationship, the intra- and inter-individual variability as well as the age dependence. The correlation and Principal Component Analyses (PCA) indicated that CP, CPO activity and total copper correlated well, followed by CuEXC, while the labile copper pool was unrelated to the other parameters.
Conclusions: This study suggests that the non-CP-bound copper species represent copper pools that are differently regulated from total copper or CP-bound copper, making them interesting complementary biomarkers to enable a more complete assessment of body copper status with potential relevance for clinical application.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.)
Databáze: MEDLINE
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