Impact of improved dead time correction on the quantification accuracy of a dedicated BrainPET scanner.

Autor: Issa ASM; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; JARA, BRAIN, Translational Medicine, Aachen, Germany.; Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Scheins J; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Tellmann L; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Brambilla CR; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Lohmann P; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Rota-Kops E; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Herzog H; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany., Neuner I; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; JARA, BRAIN, Translational Medicine, Aachen, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany., Shah NJ; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.; JARA, BRAIN, Translational Medicine, Aachen, Germany.; Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.; Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, Jülich, Germany., Lerche C; Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Apr 05; Vol. 19 (4), pp. e0296357. Date of Electronic Publication: 2024 Apr 05 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0296357
Abstrakt: Objective: Quantitative values derived from PET brain images are of high interest for neuroscientific applications. Insufficient DT correction (DTC) can lead to a systematic bias of the output parameters obtained by a detailed analysis of the time activity curves (TACs). The DTC method currently used for the Siemens 3T MR BrainPET insert is global, i.e., differences in DT losses between detector blocks are not considered, leading to inaccurate DTC and, consequently, to inaccurate measurements masked by a bias. However, following careful evaluation with phantom measurements, a new block-pairwise DTC method has demonstrated a higher degree of accuracy compared to the global DTC method.
Approach: Differences between the global and the block-pairwise DTC method were studied in this work by applying several radioactive tracers. We evaluated the impact on [11C]ABP688, O-(2-[18F]fluoroethyl)-L-tyrosine (FET), and [15O]H2O TACs.
Results: For [11C]ABP688, a relevant bias of between -0.0034 and -0.0053 ml/ (cm3 • min) was found in all studied brain regions for the volume of distribution (VT) when using the current global DTC method. For [18F]FET-PET, differences of up to 10% were observed in the tumor-to-brain ratio (TBRmax), these differences depend on the radial distance of the maximum from the PET isocenter. For [15O]H2O, differences between +4% and -7% were observed in the GM region. Average biases of -4.58%, -3.2%, and -1.2% for the regional cerebral blood flow (CBF (K1)), the rate constant k2, and the volume of distribution VT were observed, respectively. Conversely, in the white matter region, average biases of -4.9%, -7.0%, and 3.8% were observed for CBF (K1), k2, and VT, respectively.
Conclusion: The bias introduced by the global DTC method leads to an overestimation in the studied quantitative parameters for all applications compared to the block-pairwise method.
Significance: The observed differences between the two DTC methods are particularly relevant for research applications in neuroscientific studies as they affect the accuracy of quantitative Brain PET images.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Issa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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