Association Between the Endocannabinoid System-Related Gene Variants and Epilepsy.

Autor: Hosseinzadeh Anvar L; Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran., Moosavi SE; Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Charsouei S; Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. scharsouei@gmail.com., Zeinalzadeh N; Department of Animal Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran., Nikanfar M; Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Ahmadalipour A; Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. alipoura@tbzmed.ac.ir.; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. alipoura@tbzmed.ac.ir.
Jazyk: angličtina
Zdroj: Molecular neurobiology [Mol Neurobiol] 2024 Nov; Vol. 61 (11), pp. 8967-8974. Date of Electronic Publication: 2024 Apr 05.
DOI: 10.1007/s12035-024-04132-5
Abstrakt: The endocannabinoid system (ECS) is an intricate network consisting of receptors, enzymes, and endogenous ligands that play a pivotal role in various neurological processes. It has been implicated in the pathophysiology of several neurological disorders, including epilepsy. Extensive research has demonstrated the involvement of genetic factors in influencing the susceptibility to and progression of epilepsy. In this study, we focused on investigating the connection between genetic variations in genes related to the ECS and the occurrence of epilepsy. Some ECS-related gene variants were selected and genotyping was performed using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) technique. Interestingly, CNR1 rs12720071 genotype (OR 16.33, 95% CI 1.8-149; p = 0.001) showed an association with generalized epilepsy and MGLL rs604300 genotype (OR 2, 95% CI 1.1-3.4; p = 0.013) demonstrated a relationship with females diagnosed with focal epilepsy. So, studying CNR1, MGLL, and their genetic variations provides insights into the role of the endocannabinoid system in health and diseases. Moreover, they hold the potential to pave the way for the development of novel therapeutic approaches specifically targeting them.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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